Unified framework for brain connectivity-based biomarkers in neurodegenerative disorders

Sung Woo Kim, Yeong Hun Song, Hee Jin Kim, Young Noh, Sang Won Seo, Duk L. Na, Joon Kyung Seong

Research output: Contribution to journalArticlepeer-review


Background: Brain connectivity is useful for deciphering complex brain dynamics controlling interregional communication. Identifying specific brain phenomena based on brain connectivity and quantifying their levels can help explain or diagnose neurodegenerative disorders. Objective: This study aimed to establish a unified framework to identify brain connectivity-based biomarkers associated with disease progression and summarize them into a single numerical value, with consideration for connectivity-specific structural attributes. Methods: This study established a framework that unifies the processes of identifying a brain connectivity-based biomarker and mapping its abnormality level into a single numerical value, called a biomarker abnormality summarized from the identified connectivity (BASIC) score. A connectivity-based biomarker was extracted in the form of a connected component associated with disease progression. BASIC scores were constructed to maximize Kendall's rank correlation with the disease, considering the spatial autocorrelation between adjacent edges. Using functional connectivity networks, we validated the BASIC scores in various scenarios. Results: Our proposed framework was successfully applied to construct connectivity-based biomarker scores associated with disease progression, characterized by two, three, and five stages of Alzheimer's disease, and reflected the continuity of brain alterations as the diseases advanced. The BASIC scores were not only sensitive to disease progression, but also specific to the trajectory of a particular disease. Moreover, this framework can be utilized when disease stages are measured on continuous scales, resulting in a notable prediction performance when applied to the prediction of the disease. Conclusion: Our unified framework provides a method to identify brain connectivity-based biomarkers and continuity-reflecting BASIC scores that are sensitive and specific to disease progression.

Original languageEnglish
Article number975299
JournalFrontiers in Neuroscience
Publication statusPublished - 2022 Sept 20


  • Alzheimer's disease
  • Kendall's rank correlation
  • Laplacian regularization
  • biomarker scores
  • brain connectivity
  • connected component
  • connectivity-based biomarker

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Unified framework for brain connectivity-based biomarkers in neurodegenerative disorders'. Together they form a unique fingerprint.

Cite this