Uniform Microgels Containing Agglomerates of Silver Nanocubes for Molecular Size-Selectivity and High SERS Activity

Dong Jae Kim, Tae Yoon Jeon, Sung Gyu Park, Hye Ji Han, Sang Hyuk Im, Dong Ho Kim, Shin Hyun Kim

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


Surface-enhanced Raman scattering (SERS) is a promising technique for molecular analysis as the molecular fingerprints (Raman spectra) are amplified to detectable levels compared with common spectroscopy. Metal nanostructures localize electromagnetic field on their surfaces, which can lead to dramatic increase of Raman intensity of molecules adsorbed. However, the metal surfaces are prone to contamination, thereby requiring pretreatment of samples to remove adhesive molecules. To avoid the pretreatment and potentially achieve point-of-care (POC) analysis, we have developed SERS-active microgels using the droplet-microfluidic system. As the microgels are composed of water-swollen network with consistent mesh size, they selectively allow diffusion of molecules smaller than the mesh, thereby excluding large adhesives. To render the microgels highly SERS-active, we destabilize silver nanocubes to form agglomerates, which are embedded in the matrix of microgels. The nanogaps in the agglomerates provide high sensitivity in Raman measurement and size-selective permeability of the microgel matrix obviates the pretreatment of samples. To validate the functions, we demonstrate the direct detection of Aspirin dissolved in whole blood without any pretreatment.

Original languageEnglish
Article number1604048
Issue number23
Publication statusPublished - 2017 Jun 20

Bibliographical note

Funding Information:
This work was supported by the Fundamental Research Program (PNK 4660) of the Korean Institute of Materials Science (KIMS) and the Midcareer Researcher Program (2014R1A2A2A01005813) and Global Research Laboratory (NRF-2015K1A1A2033054) through the National Research Foundation (NRF) grant funded by the Ministry of Science, ICT and Future Planning (MSIP). The authors thank Prof. Jaemoon Yang at Yonsei University for providing rat blood.

Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim


  • agglomerates
  • hydrogels
  • microfluidics
  • semipermeable
  • surface-enhanced Raman scattering

ASJC Scopus subject areas

  • Engineering (miscellaneous)
  • Chemistry(all)
  • Materials Science(all)
  • Biotechnology
  • Biomaterials


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