Uniquely sized nanogels via crosslinking polymerization

Disraëli N.M. Kusmus, Thijs W. van Veldhuisen, Anzar Khan, Jeroen J.L.M. Cornelissen, Jos M.J. Paulusse

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Nanogels are very promising carriers for nanomedicine, as they can be prepared in the favorable nanometer size regime, can be functionalized with targeting agents and are responsive to stimuli, i.e. temperature and pH. This induces shrinking or swelling, resulting in controlled release of a therapeutic cargo. Our interest lies in the controlled synthesis of functional nanogels, such as those containing epoxide moieties, that can be subsequently functionalized. Co-polymerization of glycidyl methacrylate and a bifunctional methacrylate crosslinker under dilute conditions gives rise to well-defined epoxide-functional nanogels, of which the sizes are controlled by the degree of polymerization. Nanogels with well-defined sizes (polydispersity of 0.2) ranging from 38 nm to 95 nm were prepared by means of controlled radical polymerization. The nanogels were characterized in detail by FT-IR, DLS, size exclusion chromatography, NMR spectroscopy, AFM and TEM. Nucleophilic attack with functional thiols or amines on the least hindered carbon of the epoxide provides water-soluble nanogels, without altering the backbone structure, while reaction with sodium azide provides handles for further functionalization via click chemistry.

Original languageEnglish
Pages (from-to)29423-29432
Number of pages10
JournalRSC Advances
Issue number45
Publication statusPublished - 2022 Oct 14

Bibliographical note

Funding Information:
Rachèl Elzes is thanked for her help during nanogel synthesis. Dr E. G. Keim is acknowledged for his help with TEM measurements. Dr Michel Klein Gunnewiek is acknowledged for his help with AFM measurements.

Publisher Copyright:
© 2022 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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