Cells respond and actively adapt to environmental cues in the form of mechanical stimuli. This extends to immune cells and their critical role in the maintenance of tissue homeostasis. Multiple recent studies have begun illuminating underlying mechanisms of mechanosensation in modulating immune cell phenotypes. Since the extracellular microenvironment is critical to modify cellular physiology that ultimately determines the functionality of the cell, understanding the interactions between immune cells and their microenvironment is necessary. This review focuses on mechanoregulation of immune responses mediated by macrophages, dendritic cells, and T cells, in the context of modern mechanobiology.
Bibliographical noteFunding Information:
J.-K.K., Y.J.S., and L.J.H. contributed equally to this work. D.-Hw.K. appreciates the financial support from KU-KIST Graduate School of Converging Science and Technology Program, Korea University Future Research Grants, and National Research Foundation of Korea (2016R1C1B2015018). This research was also in part supported by Human Frontier Science Program Grant RGP0038/2018 (D.-Ho.K.) and the NIH/NCI Cancer Center Support Grant P30 CA015704 (D.-Ho.K.). The authors thank Fariha Rahman and Travis Moerk for their critical reading of the manuscript.
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
- immune cells
- immune response
ASJC Scopus subject areas
- Biomedical Engineering
- Pharmaceutical Science