Untreated primary hypothyroidism with simultaneous rhabdomyolysis, pericardial effusion, and sudden sensorineural hearing loss: A case report

Chung Gyo Seo, Kyoung Jin Kim, Euyhyun Park, Nam Hoon Kim, Joo Hyung Kim, Hee Young Kim, Sin Gon Kim, Kyeong Jin Kim

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    Background: Hypothyroidism, one of the prevalent endocrine disorders worldwide, has a broad spectrum of clinical manifestations, from an asymptomatic condition to myxedema coma. Although the majority of patients with hypothyroidism have minor clinical symptoms, which are recovered with levothyroxine treatment, some patients occasionally do experience fatal complications. Here we report, for the first time, the case of a patient who had hypothyroidism with simultaneous occurrence of rhabdomyolysis with acute kidney injury, moderate pericardial effusion, and sudden sensorineural hearing loss. Case presentation: A 57-year-old man with a previous history of dyslipidemia and untreated hypothyroidism was admitted to the hospital due to shortness of breath, lethargy, lower extremity discomfort, and unilateral hearing loss. Laboratory results revealed rhabdomyolysis with acute kidney injury and severe hypothyroidism. We detected cardiomegaly without lung parenchymal infiltration on chest radiography and moderate pericardial effusion on transthoracic echocardiography. We performed pure tone audiometry and identified profound unilateral sensorineural hearing loss. Aggressive fluid resuscitation, levothyroxine treatment, and systemic and intratympanic steroid therapy alleviated the patient's severe hypothyroidism, rhabdomyolysis, and pericardial effusion; however, sensorineural hearing loss was not fully recovered. Conclusions: Early recognition of life-threatening complications is important in patients with severe hypothyroidism to prevent adverse outcomes. This case suggests that hypothyroidism should be considered in patients who have rhabdomyolysis with acute kidney disease and pericardial effusion. Moreover, sudden sensorineural hearing loss should be kept in mind as a rare complication of hypothyroidism.

    Original languageEnglish
    Article number52
    JournalBMC Endocrine Disorders
    Issue number1
    Publication statusPublished - 2019 May 22

    Bibliographical note

    Publisher Copyright:
    © 2019 The Author(s).


    • Hearing loss
    • Hypothyroidism
    • Pericardial effusion
    • Rhabdomyolysis

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism


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