Up-regulation of chemokine ligand 20 in chronic rhinosinusitis

Hyouk Lee Jong; Joon Kang Hee; Jeong Soo Woo; Won Chae Sung; Hag Lee Sang; Jae Hwang Soon; Heung Man Lee

doi:10.1001/archotol.132.5.537

Up-regulation of chemokine ligand 20 in chronic rhinosinusitis

Hyouk Lee Jong, Joon Kang Hee, Jeong Soo Woo, Won Chae Sung, Hag Lee Sang, Jae Hwang Soon, Heung Man Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Objectives: To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa. Design: Prospective study. Setting: Tertiary academic institution. Patients: Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal control subjects. Interventions: Messenger RNA was extracted from the sinus mucosa, and semiquantitative reverse transcriptase-polymerase chain reaction was performed. Immunohistochemical staining was used to localize the CCL20 protein. Results: The expression levels of CCL20 messenger RNA level in chronic rhinosinusitis without nasal polyps were significantly increased compared with those in normal sinus mucosa. The expression of CCL20 protein was greater in chronic rhinosinusitis without nasal polyps mucosa and was localized to the epithelial and submucosal glandular cells. Conclusion: CCL20 is an inducible product of human paranasal sinus epithelium that may play a role in modulating mucosal immunity of the sinus mucosa.

Original language	English
Pages (from-to)	537-541
Number of pages	5
Journal	Archives of Otolaryngology - Head and Neck Surgery
Volume	132
Issue number	5
DOIs	https://doi.org/10.1001/archotol.132.5.537
Publication status	Published - 2006 May

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

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title = "Up-regulation of chemokine ligand 20 in chronic rhinosinusitis",

abstract = "Objectives: To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa. Design: Prospective study. Setting: Tertiary academic institution. Patients: Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal control subjects. Interventions: Messenger RNA was extracted from the sinus mucosa, and semiquantitative reverse transcriptase-polymerase chain reaction was performed. Immunohistochemical staining was used to localize the CCL20 protein. Results: The expression levels of CCL20 messenger RNA level in chronic rhinosinusitis without nasal polyps were significantly increased compared with those in normal sinus mucosa. The expression of CCL20 protein was greater in chronic rhinosinusitis without nasal polyps mucosa and was localized to the epithelial and submucosal glandular cells. Conclusion: CCL20 is an inducible product of human paranasal sinus epithelium that may play a role in modulating mucosal immunity of the sinus mucosa.",

author = "Jong, {Hyouk Lee} and Hee, {Joon Kang} and Woo, {Jeong Soo} and Sung, {Won Chae} and Sang, {Hag Lee} and Soon, {Jae Hwang} and Lee, {Heung Man}",

year = "2006",

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language = "English",

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AU - Jong, Hyouk Lee

AU - Hee, Joon Kang

AU - Woo, Jeong Soo

AU - Sung, Won Chae

AU - Sang, Hag Lee

AU - Soon, Jae Hwang

AU - Lee, Heung Man

PY - 2006/5

Y1 - 2006/5

N2 - Objectives: To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa. Design: Prospective study. Setting: Tertiary academic institution. Patients: Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal control subjects. Interventions: Messenger RNA was extracted from the sinus mucosa, and semiquantitative reverse transcriptase-polymerase chain reaction was performed. Immunohistochemical staining was used to localize the CCL20 protein. Results: The expression levels of CCL20 messenger RNA level in chronic rhinosinusitis without nasal polyps were significantly increased compared with those in normal sinus mucosa. The expression of CCL20 protein was greater in chronic rhinosinusitis without nasal polyps mucosa and was localized to the epithelial and submucosal glandular cells. Conclusion: CCL20 is an inducible product of human paranasal sinus epithelium that may play a role in modulating mucosal immunity of the sinus mucosa.

AB - Objectives: To investigate the up-regulation of chemokine ligand 20 (CCL20) in chronic rhinosinusitis mucosa and to localize the distribution of CCL20 in the human paranasal sinus mucosa. Design: Prospective study. Setting: Tertiary academic institution. Patients: Ten patients who underwent functional endoscopic sinus surgery for chronic rhinosinusitis without nasal polyps and 10 normal control subjects. Interventions: Messenger RNA was extracted from the sinus mucosa, and semiquantitative reverse transcriptase-polymerase chain reaction was performed. Immunohistochemical staining was used to localize the CCL20 protein. Results: The expression levels of CCL20 messenger RNA level in chronic rhinosinusitis without nasal polyps were significantly increased compared with those in normal sinus mucosa. The expression of CCL20 protein was greater in chronic rhinosinusitis without nasal polyps mucosa and was localized to the epithelial and submucosal glandular cells. Conclusion: CCL20 is an inducible product of human paranasal sinus epithelium that may play a role in modulating mucosal immunity of the sinus mucosa.

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Up-regulation of chemokine ligand 20 in chronic rhinosinusitis

Abstract

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