Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis

Tae Jun Park; Haneul Oh; Min Gyu Kim; Jaehyung Kim; Hee Joo Kim; Sang Wook Son

doi:10.1007/s13273-021-00125-w

Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis

Tae Jun Park, Haneul Oh, Min Gyu Kim, Jaehyung Kim, Hee Joo Kim, Sang Wook Son

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective: We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression. Results: Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (ρ = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition. Conclusion: Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter.

Original language	English
Pages (from-to)	195-200
Number of pages	6
Journal	Molecular and Cellular Toxicology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1007/s13273-021-00125-w
Publication status	Published - 2021 Apr

Bibliographical note

Publisher Copyright:
© 2021, The Korean Society of Toxicogenomics and Toxicoproteomics.

Keywords

Early growth response protein 1
Psoriasis
Urban particulate matter

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
General Pharmacology, Toxicology and Pharmaceutics
Health, Toxicology and Mutagenesis
Pathology and Forensic Medicine
Toxicology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13273-021-00125-w

Cite this

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title = "Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis",

abstract = "Background: Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective: We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression. Results: Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (ρ = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition. Conclusion: Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter.",

keywords = "Early growth response protein 1, Psoriasis, Urban particulate matter",

author = "Park, {Tae Jun} and Haneul Oh and Kim, {Min Gyu} and Jaehyung Kim and Kim, {Hee Joo} and Son, {Sang Wook}",

note = "Publisher Copyright: {\textcopyright} 2021, The Korean Society of Toxicogenomics and Toxicoproteomics.",

year = "2021",

month = apr,

doi = "10.1007/s13273-021-00125-w",

language = "English",

volume = "17",

pages = "195--200",

journal = "Molecular and Cellular Toxicology",

issn = "1738-642X",

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TY - JOUR

T1 - Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis

AU - Park, Tae Jun

AU - Oh, Haneul

AU - Kim, Min Gyu

AU - Kim, Jaehyung

AU - Kim, Hee Joo

AU - Son, Sang Wook

PY - 2021/4

Y1 - 2021/4

N2 - Background: Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective: We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression. Results: Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (ρ = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition. Conclusion: Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter.

AB - Background: Early growth response protein (Egr)-1 is a transcription factor important for cell growth and initiation of immune responses. It is significantly up-regulated in psoriatic skin. Objective: We evaluated the differential expression of Egr-1 in skin lesions of plaque psoriasis and its correlation with the severity of psoriasis. We also used in vitro methods in normal keratinocytes to analyze if urban particulate matter influences Egr-1 expression. Results: Egr-1 was significantly up-regulated in the psoriatic skin, specifically in the stratum basale. Its expression was positively correlated with the severity of psoriasis (ρ = 0.497, P = 0.013). It was also significantly up-regulated in keratinocytes with exposure to urban particulate matters under in vitro condition. Conclusion: Up-regulated expression of Egr-1 in the epidermis suggests that it plays a role in psoriasis by accelerating epidermal cell replication, to which could be attributed by urban particulate matter.

KW - Early growth response protein 1

KW - Psoriasis

KW - Urban particulate matter

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U2 - 10.1007/s13273-021-00125-w

DO - 10.1007/s13273-021-00125-w

M3 - Article

AN - SCOPUS:85101680970

SN - 1738-642X

VL - 17

SP - 195

EP - 200

JO - Molecular and Cellular Toxicology

JF - Molecular and Cellular Toxicology

IS - 2

ER -

Urban particulate matters induce EGR-1 expression in keratinocytes which correlates with the severity of psoriasis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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