Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging

Taekhoon Kim; Eun Jin Cho; Youngjoo Chae; Minsik Kim; Aram Oh; Juhong Jin; Eun Sook Lee; Hionsuck Baik; Seungjoo Haam; Jin Suck Suh; Yong Min Huh; Kwangyeol Lee

doi:10.1002/anie.201103108

Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T ₁ contrast agents for magnetic resonance imaging

Taekhoon Kim, Eun Jin Cho, Youngjoo Chae, Minsik Kim, Aram Oh, Juhong Jin, Eun Sook Lee, Hionsuck Baik, Seungjoo Haam, Jin Suck Suh, Yong Min Huh, Kwangyeol Lee

Research output: Contribution to journal › Article › peer-review

147 Citations (Scopus)

Abstract

Image enhancement: Core-shell MnO@Mn ₃O ₄ urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T ₁ contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low-pH sites within tumor cells lead to an enhanced T ₁ contrast image for the entire tumor mass.

Original language	English
Pages (from-to)	10589-10593
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	45
DOIs	https://doi.org/10.1002/anie.201103108
Publication status	Published - 2011 Nov 4

Keywords

anisotropic etching
crystal growth
magnetic resonance imaging
manganese
nanoparticles

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201103108

Cite this

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title = "Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging",

abstract = "Image enhancement: Core-shell MnO@Mn 3O 4 urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T 1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low-pH sites within tumor cells lead to an enhanced T 1 contrast image for the entire tumor mass.",

keywords = "anisotropic etching, crystal growth, magnetic resonance imaging, manganese, nanoparticles",

author = "Taekhoon Kim and Cho, {Eun Jin} and Youngjoo Chae and Minsik Kim and Aram Oh and Juhong Jin and Lee, {Eun Sook} and Hionsuck Baik and Seungjoo Haam and Suh, {Jin Suck} and Huh, {Yong Min} and Kwangyeol Lee",

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T1 - Urchin-shaped manganese oxide nanoparticles as pH-responsive activatable T 1 contrast agents for magnetic resonance imaging

AU - Kim, Taekhoon

AU - Cho, Eun Jin

AU - Chae, Youngjoo

AU - Kim, Minsik

AU - Oh, Aram

AU - Jin, Juhong

AU - Lee, Eun Sook

AU - Baik, Hionsuck

AU - Haam, Seungjoo

AU - Suh, Jin Suck

AU - Huh, Yong Min

AU - Lee, Kwangyeol

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AB - Image enhancement: Core-shell MnO@Mn 3O 4 urchin-shaped nanoparticles can be synthesized by means of an anisotropic etching process and used as a pH-activatable T 1 contrast agent for magnetic resonance imaging. The manganese ions released from the MnO phase in the low-pH sites within tumor cells lead to an enhanced T 1 contrast image for the entire tumor mass.

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KW - crystal growth

KW - magnetic resonance imaging

KW - manganese

KW - nanoparticles

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