Urinary ketone is associated with the heart failure severity

Ji Hyung Chung, Jin Sup Kim, Oh Yoen Kim, Seok Min Kang, Geum Sook Hwang, Min Jeong Shin

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Objectives: To test the hypothesis that urinary metabolites characterizing heart failure (HF) are associated with the magnitude of echocardiographic measurements and ultimately the severity of HF. Design/methods: Patients with systolic HF (n = 46) and control subjects (n = 32) participated in this study. Patients with type 2 diabetes mellitus were excluded. Echocardiographic measurements were performed, and selected urinary metabolites were quantified. Results: Urinary levels of acetate (p < 0.05), acetone (p < 0.01), cytosine (p < 0.001), methylmalonate (p < 0.001), and phenylacetylglycine (p < 0.01) were significantly higher, while 1-methylnicotinamide (p < 0.05) were significantly lower in HF patients than in controls. There were significant differences in E/E' (p < 0.05), urinary levels of acetate (p < 0.005), acetoacetate (p < 0.05), acetone (p < 0.05) and ketones (p < 0.01) according to the New York Heart Association (NYHA) classification in HF patients. Multiple linear regression analysis revealed that urinary ketones were found to be independent factors for both left ventricular ejection fraction and E/E' after adjusting for confounders. Conclusion: Our results showed that urinary levels of ketone bodies are associated with the magnitude of echocardiographic parameters.

Original languageEnglish
Pages (from-to)1697-1699
Number of pages3
JournalClinical Biochemistry
Issue number18
Publication statusPublished - 2012 Dec

Bibliographical note

Funding Information:
This research was supported by the Korea Basic Science Institute ( T32409 ) and the Creative Allied Project (CAP) grant funded by the Korea Research Council of Fundamental Science and Technology (KRCF) .

Copyright 2013 Elsevier B.V., All rights reserved.


  • Echocardiography
  • Ejection fraction
  • Heart failure
  • Ketones
  • Urine

ASJC Scopus subject areas

  • Clinical Biochemistry


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