Urine Neural Thread Protein Measurements in Alzheimer Disease

Young Chul Youn, Kun Woo Park, Seol Heui Han, Sang Yun Kim

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)


    Objectives: Neural thread protein (NTP), a membrane-associated phosphoprotein, was selectively elevated in the urine of patients with Alzheimer disease (AD). To demonstrate the potential utility of urine NTP assays for the diagnosis of AD, we performed this study. Design: A prospective blinded multicentered study. Participants: Individuals diagnosed as having probable AD (n = 49), Parkinson's disease (PD) (n = 20), and healthy controls (n = 22) were enrolled consecutively in 4 neurology centers. Measurements: A first morning urine sample was obtained from each subject. Urine NTP measurement using competitive ELISA was tested at the central laboratory and compared with AD and PD patients and healthy controls (HC). The testing laboratory was blinded to clinical information. Results: The mean assay value in AD (n = 49, 26.8 ± 9.4 μg/mL) was significantly higher than in HC (n = 22, 18.1 ± 6.7 μg/mL) (P ≤ .001) and than in PD (n = 20, 21.0 ± 8.5 μg/mL) (P ≤ .05). Levels of 21.6 μg/mL or higher were found in 81.6% of all AD cases, in 30.0% of PD cases, and in 13.6% of HC. Urine NTP assay measurements of AD with a Clinical Dementia Rate (CDR) of 0.5 (n = 10, 24.2 ± 5.9 μg/mL, P = .063) or of 1.0 (n = 24, 30.1 ± 10.9 μg/mL, P = .000) were significantly higher than in HC. However, the AD patients with CDR of 2.0 (n = 9, 23.1 ± 7.3 μg/mL, P = .136) were not significant. Conclusion: Urine NTP could be used as a safe and promising biochemical marker of early AD.

    Original languageEnglish
    Pages (from-to)372-376
    Number of pages5
    JournalJournal of the American Medical Directors Association
    Issue number5
    Publication statusPublished - 2011 Jun


    • Alzheimer disease
    • Biological marker
    • Neural thread protein
    • Parkinson disease

    ASJC Scopus subject areas

    • Nursing(all)
    • Health Policy
    • Geriatrics and Gerontology


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