Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile

Ji Min Lee; Gil Tae Gang; Don Kyu Kim; Yong Deuk Kim; Seung Hoi Koo; Chul Ho Lee; Hueng Sik Choi

doi:10.1074/jbc.M113.491522

Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile

Ji Min Lee, Gil Tae Gang, Don Kyu Kim, Yong Deuk Kim, Seung Hoi Koo, Chul Ho Lee, Hueng Sik Choi

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Background: Small heterodimer partner interacting leucine zipper protein (SMILE) is a nuclear corepressor of the nuclear receptor family. Results: Ursodeoxycholic acid (UDCA) increases SMILE gene expression, which contributes to inhibiting liver X receptor α (LXRα)-mediated hepatic lipogenesis. Conclusion: UDCA-induced smile inhibits LXRα-mediated hepatic lipogenic gene expression.

Original language	English
Pages (from-to)	1079-1091
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	2
DOIs	https://doi.org/10.1074/jbc.M113.491522
Publication status	Published - 2014 Jan 10

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.491522

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title = "Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile",

abstract = "Background: Small heterodimer partner interacting leucine zipper protein (SMILE) is a nuclear corepressor of the nuclear receptor family. Results: Ursodeoxycholic acid (UDCA) increases SMILE gene expression, which contributes to inhibiting liver X receptor α (LXRα)-mediated hepatic lipogenesis. Conclusion: UDCA-induced smile inhibits LXRα-mediated hepatic lipogenic gene expression.",

author = "Lee, {Ji Min} and Gang, {Gil Tae} and Kim, {Don Kyu} and Kim, {Yong Deuk} and Koo, {Seung Hoi} and Lee, {Chul Ho} and Choi, {Hueng Sik}",

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T1 - Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile

AU - Lee, Ji Min

AU - Gang, Gil Tae

AU - Kim, Don Kyu

AU - Kim, Yong Deuk

AU - Koo, Seung Hoi

AU - Lee, Chul Ho

AU - Choi, Hueng Sik

PY - 2014/1/10

Y1 - 2014/1/10

N2 - Background: Small heterodimer partner interacting leucine zipper protein (SMILE) is a nuclear corepressor of the nuclear receptor family. Results: Ursodeoxycholic acid (UDCA) increases SMILE gene expression, which contributes to inhibiting liver X receptor α (LXRα)-mediated hepatic lipogenesis. Conclusion: UDCA-induced smile inhibits LXRα-mediated hepatic lipogenic gene expression.

AB - Background: Small heterodimer partner interacting leucine zipper protein (SMILE) is a nuclear corepressor of the nuclear receptor family. Results: Ursodeoxycholic acid (UDCA) increases SMILE gene expression, which contributes to inhibiting liver X receptor α (LXRα)-mediated hepatic lipogenesis. Conclusion: UDCA-induced smile inhibits LXRα-mediated hepatic lipogenic gene expression.

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U2 - 10.1074/jbc.M113.491522

DO - 10.1074/jbc.M113.491522

M3 - Article

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AN - SCOPUS:84891909092

SN - 0021-9258

VL - 289

SP - 1079

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JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 2

ER -

Ursodeoxycholic acid inhibits liver X receptor α-mediated hepatic lipogenesis via induction of the nuclear corepressor smile

Abstract

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