Usefulness of bremsstrahlung images after intra-arterial Y-90 resin microphere radioembolization for hepatic tumors

Young Chul Kim, Yun Hwan Kim, Soon Ho Um, Yeon Seok Seo, Eun Kyung Park, Sun Young Oh, You Mie Han, Jae Gol Choe

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Purpose: Y-90 resin microsphere radioembolization is used to treat inoperable hepatic tumors. After injection of Y-90 resin microsphere, the only method to visualize the distribution of Y-90 is the scintigraphic imaging of bremsstrahlung radiation. The purpose of this study was to evaluate the characteristics and usefulness of bremsstrahlung imaging in Y-90 resin microsphere treatment. Methods: Twenty patients (22 administrations) underwent intra-arterial Y-90 resin microsphere treatment. For pretreatment planning, images of Tc-99m albumin macroaggregate (MAA) arterial injection and hepatic contrast angiography were obtained. Post-treatment bremsstrahlung images were taken and compared with pre-treatment images. The extrahepatic activity was evaluated on bremsstrahlung images. To correlate the size and vascularity of the tumors with tumor visualization on bremsstrahlung images, the individual tumors were grouped according to visualization on each image and compared with one another by size and tumor-to-normal ratio. Results: All post-therapeutic bremsstrahlung images showed similar contours of the liver with pre-treatment angiography. No extrahepatic activity was seen in all cases. The visualized tumors on bremsstrahlung images were significantly larger than the non-visualized tumors. Tumor-to-normal ratios of the visualized tumors on bremsstrahlung imageswere significantly higher than those of the non-visualized tumors. Conclusions: Bremsstrahlung images after intra-arterial Y-90 resin microsphere treatment are useful in evaluating the intrahepatic distribution of radioisotope an detecting possible extrahepatic activity.

Original languageEnglish
Pages (from-to)59-67
Number of pages9
JournalNuclear Medicine and Molecular Imaging
Issue number1
Publication statusPublished - 2011 Mar

Bibliographical note

Funding Information:
This research was supported by phase IV clinical study (HM-SS-2008) sponsored by Hoin Medibiz.


  • Bremsstrahlung
  • Hepatocellular carcinoma
  • Liver malignancy
  • Microsphere
  • Radioembolization
  • Y-90

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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