TY - JOUR
T1 - Using low tube voltage (80 kVp) quadruple phase liver CT for the detection of hepatocellular carcinoma
T2 - Two-year experience and comparison with Gd-EOB-DTPA enhanced liver MRI
AU - Lee, Chang Hee
AU - Kim, Kyeong Ah
AU - Lee, Jongmee
AU - Park, Yang Shin
AU - Choi, Jae Woong
AU - Park, Cheol Min
N1 - Funding Information:
This study was supported by a Korea University Grant . We thank Soon-Young Hwang, PhD for statistical advice and Hong Koo Kang, RT and Sung Hyun Lee, RT for conducting the low kVp CT.
PY - 2012/4
Y1 - 2012/4
N2 - Purpose: To validate the diagnostic performance of quadruple phase low tube voltage liver CT through the comparison with Gd-EOB-DTPA enhanced liver MRI for the detection of HCC. Materials and methods: Non-obese patients (38 men, eight women) with 68 HCCs underwent quadruple-phase CT at 16 MDCT (using low tube voltage, 80 kVp; moderately high tube current, 280 mAs) and Gd-EOB-DTPA-enhanced 3 T MRI. Three observers independently and randomly reviewed the CT and MR images on a tumor-by-tumor basis. The diagnostic accuracy of these techniques for detecting HCC was assessed using alternative free-response receiver operating characteristic analysis. Sensitivity and positive predictive values were evaluated. The mean effective doses for the low dose CT were also evaluated. Results: The areas under the ROC curves were 0.963, 0.959, and 0.941 for low dose CT and 0.981, 0.982, and 0.976 for MRI. Differences in Az of the two techniques for each observer were not statistically significant (P >.05). Differences in sensitivity and positive predictive values between the two techniques for each observer were not also statistically significant: sensitivity (86.8%, 82.4%, 85.3% for CT and 95.6%, 94.1%, 91.2% for MRI) and positive predictive values (92.2%, 90.3%, 89.2% for CT and 92.9%, 92.8%, 92.5% for MRI). Six HCCs (8.8%) in five patients were observed only on hepatobiliary phase of MRI, and all were smaller than 1.5 cm. The mean effective dose for CT was approximately 10.2 mSv. Conclusions: Quadruple-phase low-dose liver CT (80 kVp, 280 mAs) had relatively good diagnostic performance for detecting HCC in non-obese patients. Because no significant difference was observed between low-dose CT and MRI, the use of low-dose liver CT can be justified based on its reduced radiation effects.
AB - Purpose: To validate the diagnostic performance of quadruple phase low tube voltage liver CT through the comparison with Gd-EOB-DTPA enhanced liver MRI for the detection of HCC. Materials and methods: Non-obese patients (38 men, eight women) with 68 HCCs underwent quadruple-phase CT at 16 MDCT (using low tube voltage, 80 kVp; moderately high tube current, 280 mAs) and Gd-EOB-DTPA-enhanced 3 T MRI. Three observers independently and randomly reviewed the CT and MR images on a tumor-by-tumor basis. The diagnostic accuracy of these techniques for detecting HCC was assessed using alternative free-response receiver operating characteristic analysis. Sensitivity and positive predictive values were evaluated. The mean effective doses for the low dose CT were also evaluated. Results: The areas under the ROC curves were 0.963, 0.959, and 0.941 for low dose CT and 0.981, 0.982, and 0.976 for MRI. Differences in Az of the two techniques for each observer were not statistically significant (P >.05). Differences in sensitivity and positive predictive values between the two techniques for each observer were not also statistically significant: sensitivity (86.8%, 82.4%, 85.3% for CT and 95.6%, 94.1%, 91.2% for MRI) and positive predictive values (92.2%, 90.3%, 89.2% for CT and 92.9%, 92.8%, 92.5% for MRI). Six HCCs (8.8%) in five patients were observed only on hepatobiliary phase of MRI, and all were smaller than 1.5 cm. The mean effective dose for CT was approximately 10.2 mSv. Conclusions: Quadruple-phase low-dose liver CT (80 kVp, 280 mAs) had relatively good diagnostic performance for detecting HCC in non-obese patients. Because no significant difference was observed between low-dose CT and MRI, the use of low-dose liver CT can be justified based on its reduced radiation effects.
KW - CT
KW - GD-EOB-DTPA
KW - Hepatocellular carcinoma
KW - Low kVp CT
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=84862802708&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2011.12.033
DO - 10.1016/j.ejrad.2011.12.033
M3 - Article
C2 - 22297180
AN - SCOPUS:84862802708
SN - 0720-048X
VL - 81
SP - e605-e611
JO - European Journal of Radiology
JF - European Journal of Radiology
IS - 4
ER -