Utility of tantalum (Ta) coating to improve surface hardness in vitro bioactivity and biocompatibility of Co-Cr

Vuong Hung Pham; Seung Hee Lee; Yuanlong Li; Hyoun Ee Kim; Kwan Ha Shin; Young Hag Koh

doi:10.1016/j.tsf.2013.03.042

Utility of tantalum (Ta) coating to improve surface hardness in vitro bioactivity and biocompatibility of Co-Cr

Vuong Hung Pham, Seung Hee Lee, Yuanlong Li, Hyoun Ee Kim, Kwan Ha Shin, Young Hag Koh

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

This study reports the utility of tantalum (Ta) coating for improving the surface hardness, in vitro bioactivity and biocompatibility of Co-Cr implants. The use of direct current sputtering allowed for the deposition of a dense and uniform Ta film onto a Co-Cr substrate, which was composed of β-phase Ta grains. This hard Ta coating significantly improved the surface hardness of the Co-Cr by a factor of > 2.3. In addition, the Ta-deposited Co-Cr substrate showed a vigorous precipitation of apatite crystals on its surface after 4 weeks of immersion in simulated body fluid, suggesting its excellent in vitro bioactivity. This bioactive Ta coating led to a considerable improvement in the in vitro biocompatibility of the Co-Cr, which was assessed in terms of the attachment, proliferation and differentiation of pre-osteoblasts (MC3T3-E1).

Original language	English
Pages (from-to)	269-274
Number of pages	6
Journal	Thin Solid Films
Volume	536
DOIs	https://doi.org/10.1016/j.tsf.2013.03.042
Publication status	Published - 2013 Jun 1

Bibliographical note

Funding Information:
This research was supported by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea .

Keywords

Biomaterials
Co-Cr substrates
Cytoskeleton
Differentiation
Sputtering
Tantalum

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Surfaces and Interfaces
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1016/j.tsf.2013.03.042

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title = "Utility of tantalum (Ta) coating to improve surface hardness in vitro bioactivity and biocompatibility of Co-Cr",

abstract = "This study reports the utility of tantalum (Ta) coating for improving the surface hardness, in vitro bioactivity and biocompatibility of Co-Cr implants. The use of direct current sputtering allowed for the deposition of a dense and uniform Ta film onto a Co-Cr substrate, which was composed of β-phase Ta grains. This hard Ta coating significantly improved the surface hardness of the Co-Cr by a factor of > 2.3. In addition, the Ta-deposited Co-Cr substrate showed a vigorous precipitation of apatite crystals on its surface after 4 weeks of immersion in simulated body fluid, suggesting its excellent in vitro bioactivity. This bioactive Ta coating led to a considerable improvement in the in vitro biocompatibility of the Co-Cr, which was assessed in terms of the attachment, proliferation and differentiation of pre-osteoblasts (MC3T3-E1).",

keywords = "Biomaterials, Co-Cr substrates, Cytoskeleton, Differentiation, Sputtering, Tantalum",

author = "Pham, {Vuong Hung} and Lee, {Seung Hee} and Yuanlong Li and Kim, {Hyoun Ee} and Shin, {Kwan Ha} and Koh, {Young Hag}",

note = "Funding Information: This research was supported by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea .",

year = "2013",

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doi = "10.1016/j.tsf.2013.03.042",

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AU - Pham, Vuong Hung

AU - Lee, Seung Hee

AU - Li, Yuanlong

AU - Kim, Hyoun Ee

AU - Shin, Kwan Ha

AU - Koh, Young Hag

N1 - Funding Information: This research was supported by a grant from the Fundamental R&D Program for Core Technology of Materials funded by the Ministry of Knowledge Economy, Republic of Korea .

PY - 2013/6/1

Y1 - 2013/6/1

N2 - This study reports the utility of tantalum (Ta) coating for improving the surface hardness, in vitro bioactivity and biocompatibility of Co-Cr implants. The use of direct current sputtering allowed for the deposition of a dense and uniform Ta film onto a Co-Cr substrate, which was composed of β-phase Ta grains. This hard Ta coating significantly improved the surface hardness of the Co-Cr by a factor of > 2.3. In addition, the Ta-deposited Co-Cr substrate showed a vigorous precipitation of apatite crystals on its surface after 4 weeks of immersion in simulated body fluid, suggesting its excellent in vitro bioactivity. This bioactive Ta coating led to a considerable improvement in the in vitro biocompatibility of the Co-Cr, which was assessed in terms of the attachment, proliferation and differentiation of pre-osteoblasts (MC3T3-E1).

AB - This study reports the utility of tantalum (Ta) coating for improving the surface hardness, in vitro bioactivity and biocompatibility of Co-Cr implants. The use of direct current sputtering allowed for the deposition of a dense and uniform Ta film onto a Co-Cr substrate, which was composed of β-phase Ta grains. This hard Ta coating significantly improved the surface hardness of the Co-Cr by a factor of > 2.3. In addition, the Ta-deposited Co-Cr substrate showed a vigorous precipitation of apatite crystals on its surface after 4 weeks of immersion in simulated body fluid, suggesting its excellent in vitro bioactivity. This bioactive Ta coating led to a considerable improvement in the in vitro biocompatibility of the Co-Cr, which was assessed in terms of the attachment, proliferation and differentiation of pre-osteoblasts (MC3T3-E1).

KW - Biomaterials

KW - Co-Cr substrates

KW - Cytoskeleton

KW - Differentiation

KW - Sputtering

KW - Tantalum

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SN - 0040-6090

VL - 536

SP - 269

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JO - Thin Solid Films

JF - Thin Solid Films

ER -

Utility of tantalum (Ta) coating to improve surface hardness in vitro bioactivity and biocompatibility of Co-Cr

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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