TY - JOUR
T1 - Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus
AU - Lalou, Afroditi Despina
AU - Levrini, Virginia
AU - Garnett, Matthew
AU - Nabbanja, Eva
AU - Kim, Dong Ju
AU - Gergele, Laurent
AU - Bjornson, Anna
AU - Czosnyka, Zofia
AU - Czosnyka, Marek
N1 - Funding Information:
Funding MC and DJK are supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (grant number: HI17C1790).
Publisher Copyright:
© 2018, Springer-Verlag GmbH Austria, part of Springer Nature.
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Introduction: The so-called Davson’s equation relates baseline intracranial pressure (ICP) to resistance to cerebrospinal fluid outflow (Rout), formation of cerebrospinal fluid (I f ) and sagittal sinus pressure (P SS ) There is a controversy over whether this fundamental equation is applicable in patients with normal pressure hydrocephalus (NPH). We investigated the relationship between Rout and ICP and also other compensatory, clinical and demographic parameters in NPH patients. Method: We carried out a retrospective study of 229 patients with primary NPH who had undergone constant-rate infusion studies in our hospital. Data was recorded and processed using ICM+ software. Relationships between variables were sought by calculating Pearson product correlation coefficients and p values. Results: We found a significant, albeit weak, relationship between ICP and Rout (R = 0.17, p = 0.0049), Rout and peak-to-peak amplitude of ICP (AMP) (R = 0.27, p = 3.577e-05) and Rout and age (R = 0.16, p = 0.01306). Conclusions: The relationship found between ICP and Rout provides indirect evidence to support disturbed Cerebrospinal fluid circulation as a key factor in disturbed CSF dynamics in NPH. Weak correlation may indicate that other factors—variable P SS and formation of CSF outflow—contribute heavily to linear model expressed by Davson’s equation.
AB - Introduction: The so-called Davson’s equation relates baseline intracranial pressure (ICP) to resistance to cerebrospinal fluid outflow (Rout), formation of cerebrospinal fluid (I f ) and sagittal sinus pressure (P SS ) There is a controversy over whether this fundamental equation is applicable in patients with normal pressure hydrocephalus (NPH). We investigated the relationship between Rout and ICP and also other compensatory, clinical and demographic parameters in NPH patients. Method: We carried out a retrospective study of 229 patients with primary NPH who had undergone constant-rate infusion studies in our hospital. Data was recorded and processed using ICM+ software. Relationships between variables were sought by calculating Pearson product correlation coefficients and p values. Results: We found a significant, albeit weak, relationship between ICP and Rout (R = 0.17, p = 0.0049), Rout and peak-to-peak amplitude of ICP (AMP) (R = 0.27, p = 3.577e-05) and Rout and age (R = 0.16, p = 0.01306). Conclusions: The relationship found between ICP and Rout provides indirect evidence to support disturbed Cerebrospinal fluid circulation as a key factor in disturbed CSF dynamics in NPH. Weak correlation may indicate that other factors—variable P SS and formation of CSF outflow—contribute heavily to linear model expressed by Davson’s equation.
KW - Davson’s equation
KW - Intracranial pressure
KW - Normal pressure hydrocephalus
KW - Resistance to CSF outflow
UR - http://www.scopus.com/inward/record.url?scp=85043363528&partnerID=8YFLogxK
U2 - 10.1007/s00701-018-3497-9
DO - 10.1007/s00701-018-3497-9
M3 - Article
C2 - 29520439
AN - SCOPUS:85043363528
SN - 0001-6268
VL - 160
SP - 1097
EP - 1103
JO - Acta Neurochirurgica
JF - Acta Neurochirurgica
IS - 5
ER -