Validation of the Korean Stroop Test in Diagnosis of Minimal Hepatic Encephalopathy

Eileen L. Yoon; Dae Won Jun; Jae Yoon Jeong; Tae Yeob Kim; Do Seon Song; Sang Bong Ahn; Hee Yeon Kim; Young Kul Jung; Myeong Jun Song; Sung Eun Kim; Hyoung Su Kim; Soung Won Jeong; Sang Gyune Kim; Tae Hee Lee; Yong Kyun Cho; Jae kwan Kim; Hokyoung Ryu

doi:10.1038/s41598-019-44503-w

Validation of the Korean Stroop Test in Diagnosis of Minimal Hepatic Encephalopathy

Eileen L. Yoon, Dae Won Jun, Jae Yoon Jeong, Tae Yeob Kim, Do Seon Song, Sang Bong Ahn, Hee Yeon Kim, Young Kul Jung, Myeong Jun Song, Sung Eun Kim, Hyoung Su Kim, Soung Won Jeong, Sang Gyune Kim, Tae Hee Lee, Yong Kyun Cho, Jae kwan Kim, Hokyoung Ryu

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The burden of minimal hepatic encephalopathy (MHE) is significant, but no universal criteria for diagnosis have been established. We aimed to validate the Korean Stroop Test for MHE screening. Chronic hepatitis B-related liver cirrhosis patients were recruited prospectively from 13 centers. The Korean Stroop Test consisted of two Stroop-off states (color and word) and two Stroop-on states (inhibition and switching). Accuracy adjusted psychomotor speed (rate correct score) of these tests were analyzed. Sex- and age- adjusted rate correct scores of these tests were rated as the Korean Stroop Score (K-Stroop score). MHE was diagnosed when Portosystemic Encephalopathy Syndrome Test (PHES) scores were below −4. A total of 220 liver cirrhosis patients and 376 healthy controls were enrolled. Prevalence of MHE was 20.6% in cirrhosis patients. Rate correct scores and the K-Stroop score showed significant differences between healthy controls, cirrhosis patients without MHE, and cirrhosis patients with MHE. The rate correct score of the K-Stroop score was 0.74 (95% Confidence Interval: 0.66–0.83, P < 0.001). Female gender and the K-Stroop score were significant for MHE diagnosis. The Korean Stroop Test is simple and valid for screening of MHE.

Original language	English
Article number	8027
Journal	Scientific reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-44503-w
Publication status	Published - 2019 Dec 1

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Yoon, E. L., Jun, D. W., Jeong, J. Y., Kim, T. Y., Song, D. S., Ahn, S. B., Kim, H. Y., Jung, Y. K., Song, M. J., Kim, S. E., Kim, H. S., Jeong, S. W., Kim, S. G., Lee, T. H., Cho, Y. K., Kim, J. K., & Ryu, H. (2019). Validation of the Korean Stroop Test in Diagnosis of Minimal Hepatic Encephalopathy. Scientific reports, 9(1), [8027]. https://doi.org/10.1038/s41598-019-44503-w

@article{61fef295cd824df6bd0706c9cc563a72,

title = "Validation of the Korean Stroop Test in Diagnosis of Minimal Hepatic Encephalopathy",

abstract = "The burden of minimal hepatic encephalopathy (MHE) is significant, but no universal criteria for diagnosis have been established. We aimed to validate the Korean Stroop Test for MHE screening. Chronic hepatitis B-related liver cirrhosis patients were recruited prospectively from 13 centers. The Korean Stroop Test consisted of two Stroop-off states (color and word) and two Stroop-on states (inhibition and switching). Accuracy adjusted psychomotor speed (rate correct score) of these tests were analyzed. Sex- and age- adjusted rate correct scores of these tests were rated as the Korean Stroop Score (K-Stroop score). MHE was diagnosed when Portosystemic Encephalopathy Syndrome Test (PHES) scores were below −4. A total of 220 liver cirrhosis patients and 376 healthy controls were enrolled. Prevalence of MHE was 20.6% in cirrhosis patients. Rate correct scores and the K-Stroop score showed significant differences between healthy controls, cirrhosis patients without MHE, and cirrhosis patients with MHE. The rate correct score of the K-Stroop score was 0.74 (95% Confidence Interval: 0.66–0.83, P < 0.001). Female gender and the K-Stroop score were significant for MHE diagnosis. The Korean Stroop Test is simple and valid for screening of MHE.",

author = "Yoon, {Eileen L.} and Jun, {Dae Won} and Jeong, {Jae Yoon} and Kim, {Tae Yeob} and Song, {Do Seon} and Ahn, {Sang Bong} and Kim, {Hee Yeon} and Jung, {Young Kul} and Song, {Myeong Jun} and Kim, {Sung Eun} and Kim, {Hyoung Su} and Jeong, {Soung Won} and Kim, {Sang Gyune} and Lee, {Tae Hee} and Cho, {Yong Kyun} and Kim, {Jae kwan} and Hokyoung Ryu",

note = "Funding Information: DaiSeg Bai, Division of Clinical Psychology, Department of Psychiatry, Yeungnam University Hospital, Daegu, Korea. This study was supported by The Research Supporting Program of The Korean Association for the Study of the Liver and The Korean Liver Foundation (Grant Number: KASLKLF2016-04), and was independent of its support sources. Publisher Copyright: {\textcopyright} 2019, The Author(s).",

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doi = "10.1038/s41598-019-44503-w",

language = "English",

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T1 - Validation of the Korean Stroop Test in Diagnosis of Minimal Hepatic Encephalopathy

AU - Yoon, Eileen L.

AU - Jun, Dae Won

AU - Jeong, Jae Yoon

AU - Kim, Tae Yeob

AU - Song, Do Seon

AU - Ahn, Sang Bong

AU - Kim, Hee Yeon

AU - Jung, Young Kul

AU - Song, Myeong Jun

AU - Kim, Sung Eun

AU - Kim, Hyoung Su

AU - Jeong, Soung Won

AU - Kim, Sang Gyune

AU - Lee, Tae Hee

AU - Cho, Yong Kyun

AU - Kim, Jae kwan

AU - Ryu, Hokyoung

N1 - Funding Information: DaiSeg Bai, Division of Clinical Psychology, Department of Psychiatry, Yeungnam University Hospital, Daegu, Korea. This study was supported by The Research Supporting Program of The Korean Association for the Study of the Liver and The Korean Liver Foundation (Grant Number: KASLKLF2016-04), and was independent of its support sources. Publisher Copyright: © 2019, The Author(s).

PY - 2019/12/1

Y1 - 2019/12/1

N2 - The burden of minimal hepatic encephalopathy (MHE) is significant, but no universal criteria for diagnosis have been established. We aimed to validate the Korean Stroop Test for MHE screening. Chronic hepatitis B-related liver cirrhosis patients were recruited prospectively from 13 centers. The Korean Stroop Test consisted of two Stroop-off states (color and word) and two Stroop-on states (inhibition and switching). Accuracy adjusted psychomotor speed (rate correct score) of these tests were analyzed. Sex- and age- adjusted rate correct scores of these tests were rated as the Korean Stroop Score (K-Stroop score). MHE was diagnosed when Portosystemic Encephalopathy Syndrome Test (PHES) scores were below −4. A total of 220 liver cirrhosis patients and 376 healthy controls were enrolled. Prevalence of MHE was 20.6% in cirrhosis patients. Rate correct scores and the K-Stroop score showed significant differences between healthy controls, cirrhosis patients without MHE, and cirrhosis patients with MHE. The rate correct score of the K-Stroop score was 0.74 (95% Confidence Interval: 0.66–0.83, P < 0.001). Female gender and the K-Stroop score were significant for MHE diagnosis. The Korean Stroop Test is simple and valid for screening of MHE.

AB - The burden of minimal hepatic encephalopathy (MHE) is significant, but no universal criteria for diagnosis have been established. We aimed to validate the Korean Stroop Test for MHE screening. Chronic hepatitis B-related liver cirrhosis patients were recruited prospectively from 13 centers. The Korean Stroop Test consisted of two Stroop-off states (color and word) and two Stroop-on states (inhibition and switching). Accuracy adjusted psychomotor speed (rate correct score) of these tests were analyzed. Sex- and age- adjusted rate correct scores of these tests were rated as the Korean Stroop Score (K-Stroop score). MHE was diagnosed when Portosystemic Encephalopathy Syndrome Test (PHES) scores were below −4. A total of 220 liver cirrhosis patients and 376 healthy controls were enrolled. Prevalence of MHE was 20.6% in cirrhosis patients. Rate correct scores and the K-Stroop score showed significant differences between healthy controls, cirrhosis patients without MHE, and cirrhosis patients with MHE. The rate correct score of the K-Stroop score was 0.74 (95% Confidence Interval: 0.66–0.83, P < 0.001). Female gender and the K-Stroop score were significant for MHE diagnosis. The Korean Stroop Test is simple and valid for screening of MHE.

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U2 - 10.1038/s41598-019-44503-w

DO - 10.1038/s41598-019-44503-w

M3 - Article

C2 - 31142824

AN - SCOPUS:85067045200

SN - 2045-2322

VL - 9

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 8027

ER -

Validation of the Korean Stroop Test in Diagnosis of Minimal Hepatic Encephalopathy

Abstract

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