Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain

Gye Sun Jeon, Sang Ha Park, Kuem Ju Lee, Min Soo Lee, Boe Gwun Chun, Kyung Ho Shin

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.

    Original languageEnglish
    Pages (from-to)142-146
    Number of pages5
    JournalEuropean Journal of Pharmacology
    Issue number2-3
    Publication statusPublished - 2006 Sept 18

    Bibliographical note

    Funding Information:
    This research was supported by a grant from the Brain Research Center of the 21st Century Frontier Research Program, funded by the Korean Ministry of Science and Technology (M103KV010007-03K2201-00720), Brain Korea 21 Project in 2006 and Korea Health 21 R&D Project (KPGRN-R-04-04) by the Ministry of Health and Welfare, Republic of Korea.

    Copyright 2008 Elsevier B.V., All rights reserved.


    • BDNF (brain-derived neurotrophic factor)
    • MK801
    • Retrosplenial cortex
    • Valproate

    ASJC Scopus subject areas

    • Pharmacology


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