Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain

Gye Sun Jeon; Sang Ha Park; Kuem Ju Lee; Min Soo Lee; Boe Gwun Chun; Kyung Ho Shin

doi:10.1016/j.ejphar.2006.06.046

Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain

Gye Sun Jeon
, Sang Ha Park
, Kuem Ju Lee
, Min Soo Lee
, Boe Gwun Chun
, Kyung Ho Shin^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.

Original language	English
Pages (from-to)	142-146
Number of pages	5
Journal	European Journal of Pharmacology
Volume	545
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ejphar.2006.06.046
Publication status	Published - 2006 Sept 18
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by a grant from the Brain Research Center of the 21st Century Frontier Research Program, funded by the Korean Ministry of Science and Technology (M103KV010007-03K2201-00720), Brain Korea 21 Project in 2006 and Korea Health 21 R&D Project (KPGRN-R-04-04) by the Ministry of Health and Welfare, Republic of Korea.

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

BDNF (brain-derived neurotrophic factor)
MK801
Retrosplenial cortex
Valproate

ASJC Scopus subject areas

Pharmacology

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10.1016/j.ejphar.2006.06.046

Cite this

@article{74fc1336014a42d6ae14fa6d14d4034e,

title = "Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain",

abstract = "To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.",

keywords = "BDNF (brain-derived neurotrophic factor), MK801, Retrosplenial cortex, Valproate",

author = "Jeon, \{Gye Sun\} and Park, \{Sang Ha\} and Lee, \{Kuem Ju\} and Lee, \{Min Soo\} and Chun, \{Boe Gwun\} and Shin, \{Kyung Ho\}",

note = "Funding Information: This research was supported by a grant from the Brain Research Center of the 21st Century Frontier Research Program, funded by the Korean Ministry of Science and Technology (M103KV010007-03K2201-00720), Brain Korea 21 Project in 2006 and Korea Health 21 R\&D Project (KPGRN-R-04-04) by the Ministry of Health and Welfare, Republic of Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2006",

month = sep,

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doi = "10.1016/j.ejphar.2006.06.046",

language = "English",

volume = "545",

pages = "142--146",

journal = "European Journal of Pharmacology",

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T1 - Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain

AU - Jeon, Gye Sun

AU - Park, Sang Ha

AU - Lee, Kuem Ju

AU - Lee, Min Soo

AU - Chun, Boe Gwun

AU - Shin, Kyung Ho

N1 - Funding Information: This research was supported by a grant from the Brain Research Center of the 21st Century Frontier Research Program, funded by the Korean Ministry of Science and Technology (M103KV010007-03K2201-00720), Brain Korea 21 Project in 2006 and Korea Health 21 R&D Project (KPGRN-R-04-04) by the Ministry of Health and Welfare, Republic of Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2006/9/18

Y1 - 2006/9/18

N2 - To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.

AB - To investigate whether the anticonvulsant valproate influences the changes in brain-derived neurotrophic factor (BDNF) mRNA expression induced by MK801 in rat brain, we injected valproate prior to MK801 and observed the changes in the BDNF expression 3 h later. MK801 significantly increased BDNF expression in the retrosplenial and entorhinal cortex, and these increases were prevented by valproate pretreatment. Valproate pretreatment significantly blocked the MK801-induced increase of BDNF expression in retrosplenial cortex at 3 h, 6 h, and 9 h after MK801 injection, suggesting that valproate pretreatment did not delay the MK801-induced increase of BDNF expression. However, MK801 significantly decreased BDNF expression in the granule cell layer of hippocampus, and valproate pretreatment before MK801 potentiated the MK801-induced decrease in BDNF expression in granule cell layer. These results indicate that valproate pretreatment differentially affects the MK801-induced changes in BDNF expression in a region-selective manner.

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KW - Retrosplenial cortex

KW - Valproate

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IS - 2-3

ER -

Valproate prevents MK801-induced changes in brain-derived neurotrophic factor mRNA in the rat brain

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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