TY - JOUR
T1 - Variation of retinal and choroidal vasculatures in patients with age-related macular degeneration
AU - Lee, Boram
AU - Ahn, Jaemoon
AU - Yun, Cheolmin
AU - Kim, Seong Woo
AU - Oh, Jaeryung
N1 - Funding Information:
Supported by a grant from Korea University (K1620061). Disclosure: B. Lee, None; J. Ahn, None; C. Yun, None; S.-w. Kim, None; J. Oh, None
Publisher Copyright:
© 2018 The Authors.
PY - 2018/10
Y1 - 2018/10
N2 - PURPOSE. To investigate variations in chorioretinal �vasculatures in fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD). METHODS. We included fellow eyes of consecutive patients with unilateral nAMD from swept source optical coherence tomography (SS-OCT) angiography database. Vascular and nonvascular indices were determined based on SS-OCT and SS-OCT angiography images. Variation of the vascular or nonvascular index was compared between fellow eyes with and without early AMD. RESULTS. In 146 fellow eyes, 88 (60.3%) had early AMD and 58 (39.7%) had a normal fundus. Vascular density (VD) values of the superficial and deep retinal capillary plexus and choriocapillaris were smaller in eyes with early AMD than in those without (P < 0.001, P = 0.001, P = 0.006, respectively). Flow void area in choriocapillaris was greater in eyes with early AMD than those without (P = 0.015). In 88 fellow eyes with early AMD, vascular indices of the retina were correlated with those of choroid while nonvascular indices were not. Fellow eyes of patients with classic exudative AMD had greater foveal avascular zone area and smaller VD values of the deep retinal capillary plexus than those with polypoidal choroidal vasculopathy (P < 0.001, P = 0.004). CONCLUSIONS. In addition to vascular insufficiency in the choroid or choriocapillaris, retinal vascular alteration was apparent in eyes with early AMD. It may suggest that retinal vessels were involved in the pathogenesis of AMD even while changes in nonvascular components of the retina were not yet apparent.
AB - PURPOSE. To investigate variations in chorioretinal �vasculatures in fellow eyes of patients with unilateral neovascular age-related macular degeneration (nAMD). METHODS. We included fellow eyes of consecutive patients with unilateral nAMD from swept source optical coherence tomography (SS-OCT) angiography database. Vascular and nonvascular indices were determined based on SS-OCT and SS-OCT angiography images. Variation of the vascular or nonvascular index was compared between fellow eyes with and without early AMD. RESULTS. In 146 fellow eyes, 88 (60.3%) had early AMD and 58 (39.7%) had a normal fundus. Vascular density (VD) values of the superficial and deep retinal capillary plexus and choriocapillaris were smaller in eyes with early AMD than in those without (P < 0.001, P = 0.001, P = 0.006, respectively). Flow void area in choriocapillaris was greater in eyes with early AMD than those without (P = 0.015). In 88 fellow eyes with early AMD, vascular indices of the retina were correlated with those of choroid while nonvascular indices were not. Fellow eyes of patients with classic exudative AMD had greater foveal avascular zone area and smaller VD values of the deep retinal capillary plexus than those with polypoidal choroidal vasculopathy (P < 0.001, P = 0.004). CONCLUSIONS. In addition to vascular insufficiency in the choroid or choriocapillaris, retinal vascular alteration was apparent in eyes with early AMD. It may suggest that retinal vessels were involved in the pathogenesis of AMD even while changes in nonvascular components of the retina were not yet apparent.
KW - Age-related macular degeneration
KW - Choriocapillaris
KW - Choroidal vasculature
KW - Optical coherence tomography angiography
KW - Retinal vasculature
UR - http://www.scopus.com/inward/record.url?scp=85055816870&partnerID=8YFLogxK
U2 - 10.1167/iovs.17-23600
DO - 10.1167/iovs.17-23600
M3 - Article
C2 - 30383196
AN - SCOPUS:85055816870
SN - 0146-0404
VL - 59
SP - 5246
EP - 5255
JO - Investigative Ophthalmology and Visual Science
JF - Investigative Ophthalmology and Visual Science
IS - 12
ER -