Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review

Yoon Jung Boo; Jason C. Fisher; Mary Jo Haley; Robert A. Cowles; Jessica J. Kandel; Darrell J. Yamashiro

doi:10.1016/j.jpedsurg.2009.06.023

Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review

Yoon Jung Boo, Jason C. Fisher, Mary Jo Haley, Robert A. Cowles, Jessica J. Kandel, Darrell J. Yamashiro

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.

Original language	English
Pages (from-to)	2031-2036
Number of pages	6
Journal	Journal of Pediatric Surgery
Volume	44
Issue number	10
DOIs	https://doi.org/10.1016/j.jpedsurg.2009.06.023
Publication status	Published - 2009 Oct

Keywords

Angiopoietin
Clear cell sarcoma of the kidney
Notch
Vascular endothelial growth factor
c-KIT

ASJC Scopus subject areas

Surgery
Pediatrics, Perinatology, and Child Health

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10.1016/j.jpedsurg.2009.06.023

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title = "Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review",

abstract = "Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.",

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T2 - a case report and review

AU - Boo, Yoon Jung

AU - Fisher, Jason C.

AU - Haley, Mary Jo

AU - Cowles, Robert A.

AU - Kandel, Jessica J.

AU - Yamashiro, Darrell J.

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AB - Clear cell sarcoma of the kidney (CCSK) is uncommon pediatric renal tumor and can present a significant therapeutic challenge in those patients whose tumors spread beyond the kidney. Thus, identifying potential novel targets for treatment may be clinically important. Clear cell sarcoma of the kidney is characterized by a unique vascular pattern, in which nests of tumor cells are separated by regularly-spaced, fine fibrovascular septa. This distinctive histopathology raises the possibility that understanding the factors which drive angiogenesis in CCSK tumors may suggest new therapeutic targets. Here, we describe a case of CCSK and present immunohistochemical studies of its vasculature.

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KW - Clear cell sarcoma of the kidney

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KW - Vascular endothelial growth factor

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Vascular characterization of clear cell sarcoma of the kidney in a child: a case report and review

Abstract

Keywords

ASJC Scopus subject areas

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