Vascular Function and Frailty in Community-Dwelling Older Individuals

Wonil Park, Jaesung Lee, Hun Young Park, Saejong Park, Jonghoon Park

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background: Frailty is a condition characterized by a state of reduced physiological reserve and increased vulnerability to stressors. Frail individuals have a higher likelihood of developing cardiovascular disease (CVD). However, the mechanisms underlying the association between frailty and CVD remain unclear. Objectives: This study investigated whether frailty is associated with vascular function in community-dwelling older individuals. Material and Methods: We conducted a cross-sectional analysis of 92 community-dwelling individuals aged ≥ 65 years, including 30 non-frail, 43 pre-frail, 19 frail individuals. Vascular function was assessed by brachial-ankle pulse wave velocity (PWV, measuring arterial stiffness) and flow-mediated dilation of the brachial artery (FMD, measuring endothelial function). Results: The PWV was significantly higher in both pre-frail and frail groups than in the non-frail group (non-frail: 1615.7 ± 209.9 cm/s vs. pre-frail: 1815.2 ± 265.0 cm/s vs. frail: 1829.9 ± 256.0 cm/s, respectively, p = 0.003). The FMD was significantly lower in both pre-frail and frail groups than in the non-frail group (non-frail: 5.1 ± 2.1% vs. pre-frail: 3.4 ± 1.3% vs. frail: 3.1 ± 1.2% cm/s, respectively, p = 0.001). Multiple logistic regression analyses indicated that pre-frail and frail group were associated with arterial stiffness (OR, 2.92; 95% CI, 1.01–8.42; OR, 3.56; 95% CI, 0.85–14.91) and endothelial dysfunction (OR, 2.17; 95% CI, 0.41–3.09; OR, 2.27; 95% CI, 0.31–6.97). Conclusions: Thus, pre-frailty and frailty are associated with impaired vascular function in community-dwelling older adults, even when adjusting for confounding factors. These findings may help to prevent the potential consequences between CVD and frailty in community-dwelling older individuals.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalArtery Research
Issue number1
Publication statusPublished - 2022 Mar

Bibliographical note

Funding Information:
This research was sup-ported by NRF (National Research Foundation of Korea) Grant funded by the Korean Government (NRF-2017-Fostering Core Leaders of the Future Basic Science Pro-gram/Global Ph.D. Fellowship Program).

Publisher Copyright:
© 2022, The Author(s).


  • Flow-mediated dilation
  • Frailty
  • Pulse wave velocity
  • Vascular function

ASJC Scopus subject areas

  • Anatomy
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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