TY - JOUR
T1 - VEGF overexpression predicts poor survival in hepatocellular carcinoma
AU - Choi, Sae Byeol
AU - Han, Hyung Joon
AU - Kim, Wan Bae
AU - Song, Tae Jin
AU - Choi, Sang Yong
N1 - Funding Information:
provided by the Korea University Guro Hospital of Biobank. This research was supported by a faculty research grant from the Korea University (grant number, K0931191).
Publisher Copyright:
© 2017 Sae Byeol Choi, et al.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection. 234 patients with HCC following surgical resection were enrolled. Clinicopathological and survival data were analyzed, and immunohistochemical staining was performed on tissue microarray sections using the anti-VEGF, anti-Akt, anti-HSP70, and anti-HSP27 antibodies. The 3-A nd 5-year overall survival rates were 86.5 and 81.54%, respectively. Multivariate analysis revealed that VEGF expression (P = 0.017, HR = 2.573) and T stage (P < 0.001, HR = 4.953) were independent prognostic factors for overall survival. Immunohistochemical staining showed that the expression of Akt, HSP70, and HSP27 did not affect the overall survival rate. The 3-A nd 5-year disease-free survival rates were 58.2 and 49.4%, respectively. Compared to the VEGF(-)/(+) group, the VEGF(++)/(+++) group demonstrated significantly higher proportion of patients with AFP levels > 400 ng/mL, capsule invasion, and microvascular invasion. VEGF overexpression was associated with capsule invasion, microvascular invasion, and a poor overall survival rate.
AB - The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection. 234 patients with HCC following surgical resection were enrolled. Clinicopathological and survival data were analyzed, and immunohistochemical staining was performed on tissue microarray sections using the anti-VEGF, anti-Akt, anti-HSP70, and anti-HSP27 antibodies. The 3-A nd 5-year overall survival rates were 86.5 and 81.54%, respectively. Multivariate analysis revealed that VEGF expression (P = 0.017, HR = 2.573) and T stage (P < 0.001, HR = 4.953) were independent prognostic factors for overall survival. Immunohistochemical staining showed that the expression of Akt, HSP70, and HSP27 did not affect the overall survival rate. The 3-A nd 5-year disease-free survival rates were 58.2 and 49.4%, respectively. Compared to the VEGF(-)/(+) group, the VEGF(++)/(+++) group demonstrated significantly higher proportion of patients with AFP levels > 400 ng/mL, capsule invasion, and microvascular invasion. VEGF overexpression was associated with capsule invasion, microvascular invasion, and a poor overall survival rate.
KW - Hepatocellular carcinoma
KW - VEGF
KW - hepatic resection
KW - prognostic marker
UR - http://www.scopus.com/inward/record.url?scp=85040358715&partnerID=8YFLogxK
U2 - 10.1515/med-2017-0061
DO - 10.1515/med-2017-0061
M3 - Article
AN - SCOPUS:85040358715
SN - 2391-5463
VL - 12
SP - 430
EP - 439
JO - Open Medicine (Poland)
JF - Open Medicine (Poland)
IS - 1
ER -