View-aligned hypergraph learning for Alzheimer's disease diagnosis with incomplete multi-modality data

Mingxia Liu, Jun Zhang, Pew Thian Yap, Dinggang Shen

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


Effectively utilizing incomplete multi-modality data for the diagnosis of Alzheimer's disease (AD) and its prodrome (i.e., mild cognitive impairment, MCI) remains an active area of research. Several multi-view learning methods have been recently developed for AD/MCI diagnosis by using incomplete multi-modality data, with each view corresponding to a specific modality or a combination of several modalities. However, existing methods usually ignore the underlying coherence among views, which may lead to sub-optimal learning performance. In this paper, we propose a view-aligned hypergraph learning (VAHL) method to explicitly model the coherence among views. Specifically, we first divide the original data into several views based on the availability of different modalities and then construct a hypergraph in each view space based on sparse representation. A view-aligned hypergraph classification (VAHC) model is then proposed, by using a view-aligned regularizer to capture coherence among views. We further assemble the class probability scores generated from VAHC, via a multi-view label fusion method for making a final classification decision. We evaluate our method on the baseline ADNI-1 database with 807 subjects and three modalities (i.e., MRI, PET, and CSF). Experimental results demonstrate that our method outperforms state-of-the-art methods that use incomplete multi-modality data for AD/MCI diagnosis.

Original languageEnglish
Pages (from-to)123-134
Number of pages12
JournalMedical Image Analysis
Publication statusPublished - 2017 Feb 1


  • Alzheimer's disease
  • Classification
  • Incomplete data
  • Multi-modality

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Computer Vision and Pattern Recognition
  • Health Informatics
  • Computer Graphics and Computer-Aided Design


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