Viral shedding from diverse body fluids in a patient with severe fever with thrombocytopenia syndrome

Eun Ju Jeong, Joon Young Song, Chae Seung Lim, Ilseob Lee, Man Seong Park, Min Joo Choi, Ji Ho Jeon, Seong Hui Kang, Bo Kyeung Jung, Jin Gu Yoon, Hak Jun Hyun, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)


Background: Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne disease characterized by high fever, thrombocytopenia, leukopenia, and multiple organ failure and is caused by a novel bunyavirus. Human-to-human transmission has been reported previously, but the mode of transmission has not been clarified thoroughly. Study design: We identified a case of a 73-year-old woman with SFTS and performed a semi-quantitative real-time reverse transcription PCR (real-time RT-PCR) assay on her blood, tracheal aspirate, gastric aspirate and urine to detect SFTS virus (SFTSV). Results: During 7-day hospitalization, all the serum samples showed positive Ct values lower than 35 in both the S and M segments, suggesting the presence of the SFTSV RNA. After initiation of plasma exchange, serum SFTSV load markedly decreased, but still remained positive. The SFTS viral RNA was also detected in other body fluids, including tracheal aspirate and gastric aspirate. Conclusion: These results suggest that droplet transmission can occur through close contact with infected patients.

Original languageEnglish
Pages (from-to)33-35
Number of pages3
JournalJournal of Clinical Virology
Publication statusPublished - 2016 Jul 1

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Healthcare Technology R&D Project of the Ministry of Health & Welfare of the Republic of Korea (No. A103001 ).

Publisher Copyright:
© 2016 Elsevier B.V..


  • Bunyaviridae infections
  • Disease transmission
  • Phlebovirus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases


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