Abstract
A study investigates a new biocompatible nanoplatform using an engineered exosome to transfer functional membrane proteins directly into cellular membranes. This modification of plasma membranes is called ‘membrane-editing’. The biologically originated factors promoting fusion, such as viral fusion components on the exosome surfaces, are valid biochemical techniques that give rise to high fusion efficiencies. The study has used vascular stomatitis virus (VSV)-G protein, which is routinely used to enhance the target range and transduction efficiency of retroviruses by providing wider tropism, improving viral stability, and augmenting resistance to complement inactivation. The VSV-G protein is a low-pH-activated viral fusogen that enables highly effective membrane fusion without adverse effects.
| Original language | English |
|---|---|
| Article number | 1605604 |
| Journal | Advanced Materials |
| Volume | 29 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2017 Apr 4 |
Bibliographical note
Funding Information:This work was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (Grant No. 1420390), and the KIST Institutional Program (Project No. 2E26320). The experiments were designed by Y.Y. and I.-S.K. The experiments were performed by Y.Y., Y.H., G.-H.N., E.K., and J.H.J. Y.Y. and I.-S.K. wrote the manuscript. The authors declare no competing financial interests.
Keywords
- exosomes
- membrane protein
- nanoplatform
- viral fusogen
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering