Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses

Woo Chang Chung; Moon Jung Song

doi:10.3389/fmicb.2021.811671

Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses

Woo Chang Chung, Moon Jung Song

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

The gammaherpesviruses, include the Epstein–Barr virus, Kaposi’s sarcoma-associated herpesvirus, and murine gammaherpesvirus 68. They establish latent infection in the B lymphocytes and are associated with various lymphoproliferative diseases and tumors. The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. In gammaherpesvirus infection, PARP1 acts as a key regulator of the virus life cycle: lytic replication and latency. These viruses also develop various strategies to regulate PARP1, facilitating their replication. This review summarizes the roles of PARP1 in the viral life cycle as well as the viral modulation of host PARP1 activity and discusses the implications. Understanding the interactions between the PARP1 and oncogenic gammaherpesviruses may lead to the identification of effective therapeutic targets for the associated diseases.

Original language	English
Article number	811671
Journal	Frontiers in Microbiology
Volume	12
DOIs	https://doi.org/10.3389/fmicb.2021.811671
Publication status	Published - 2022 Jan 14

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants, the Bio and Medical Technology Development Program, and the Basic Research Laboratory Program of NRF funded by the Korea government

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grants, the Bio and Medical Technology Development Program, and the Basic Research Laboratory Program of NRF funded by the Korea government (MSIT) (Nos. 2020R1A2C2013827, 2021M3A9I2080487, and 2020R1A4A1018019). W-CC was supported, in part, by a postdoctoral research grant funded by MSIT (No. NRF2019R1A6A3A01093571).

Publisher Copyright:
Copyright © 2022 Chung and Song.

Keywords

ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1)
Epstein-Barr virus (EBV)
Kaposi’s sarcoma-associated herpesvirus (KSHV)
gammaherpesvirus replication
murine gammaherpesvirus 68 (MHV-68)
poly (ADP-ribose) polymerase 1 (PARP1)
virus-host interaction

ASJC Scopus subject areas

Microbiology
Microbiology (medical)

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10.3389/fmicb.2021.811671

Cite this

@article{a80296bef77d444f842e897a8b81aa79,

title = "Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses",

abstract = "The gammaherpesviruses, include the Epstein–Barr virus, Kaposi{\textquoteright}s sarcoma-associated herpesvirus, and murine gammaherpesvirus 68. They establish latent infection in the B lymphocytes and are associated with various lymphoproliferative diseases and tumors. The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. In gammaherpesvirus infection, PARP1 acts as a key regulator of the virus life cycle: lytic replication and latency. These viruses also develop various strategies to regulate PARP1, facilitating their replication. This review summarizes the roles of PARP1 in the viral life cycle as well as the viral modulation of host PARP1 activity and discusses the implications. Understanding the interactions between the PARP1 and oncogenic gammaherpesviruses may lead to the identification of effective therapeutic targets for the associated diseases.",

keywords = "ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1), Epstein-Barr virus (EBV), Kaposi{\textquoteright}s sarcoma-associated herpesvirus (KSHV), gammaherpesvirus replication, murine gammaherpesvirus 68 (MHV-68), poly (ADP-ribose) polymerase 1 (PARP1), virus-host interaction",

author = "Chung, {Woo Chang} and Song, {Moon Jung}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants, the Bio and Medical Technology Development Program, and the Basic Research Laboratory Program of NRF funded by the Korea government Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants, the Bio and Medical Technology Development Program, and the Basic Research Laboratory Program of NRF funded by the Korea government (MSIT) (Nos. 2020R1A2C2013827, 2021M3A9I2080487, and 2020R1A4A1018019). W-CC was supported, in part, by a postdoctoral research grant funded by MSIT (No. NRF2019R1A6A3A01093571). Publisher Copyright: Copyright {\textcopyright} 2022 Chung and Song.",

year = "2022",

month = jan,

day = "14",

doi = "10.3389/fmicb.2021.811671",

language = "English",

volume = "12",

journal = "Frontiers in Microbiology",

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AU - Song, Moon Jung

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants, the Bio and Medical Technology Development Program, and the Basic Research Laboratory Program of NRF funded by the Korea government Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grants, the Bio and Medical Technology Development Program, and the Basic Research Laboratory Program of NRF funded by the Korea government (MSIT) (Nos. 2020R1A2C2013827, 2021M3A9I2080487, and 2020R1A4A1018019). W-CC was supported, in part, by a postdoctoral research grant funded by MSIT (No. NRF2019R1A6A3A01093571). Publisher Copyright: Copyright © 2022 Chung and Song.

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N2 - The gammaherpesviruses, include the Epstein–Barr virus, Kaposi’s sarcoma-associated herpesvirus, and murine gammaherpesvirus 68. They establish latent infection in the B lymphocytes and are associated with various lymphoproliferative diseases and tumors. The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. In gammaherpesvirus infection, PARP1 acts as a key regulator of the virus life cycle: lytic replication and latency. These viruses also develop various strategies to regulate PARP1, facilitating their replication. This review summarizes the roles of PARP1 in the viral life cycle as well as the viral modulation of host PARP1 activity and discusses the implications. Understanding the interactions between the PARP1 and oncogenic gammaherpesviruses may lead to the identification of effective therapeutic targets for the associated diseases.

AB - The gammaherpesviruses, include the Epstein–Barr virus, Kaposi’s sarcoma-associated herpesvirus, and murine gammaherpesvirus 68. They establish latent infection in the B lymphocytes and are associated with various lymphoproliferative diseases and tumors. The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. In gammaherpesvirus infection, PARP1 acts as a key regulator of the virus life cycle: lytic replication and latency. These viruses also develop various strategies to regulate PARP1, facilitating their replication. This review summarizes the roles of PARP1 in the viral life cycle as well as the viral modulation of host PARP1 activity and discusses the implications. Understanding the interactions between the PARP1 and oncogenic gammaherpesviruses may lead to the identification of effective therapeutic targets for the associated diseases.

KW - ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1)

KW - Epstein-Barr virus (EBV)

KW - Kaposi’s sarcoma-associated herpesvirus (KSHV)

KW - gammaherpesvirus replication

KW - murine gammaherpesvirus 68 (MHV-68)

KW - poly (ADP-ribose) polymerase 1 (PARP1)

KW - virus-host interaction

UR - http://www.scopus.com/inward/record.url?scp=85123959201&partnerID=8YFLogxK

U2 - 10.3389/fmicb.2021.811671

DO - 10.3389/fmicb.2021.811671

M3 - Review article

AN - SCOPUS:85123959201

SN - 1664-302X

VL - 12

JO - Frontiers in Microbiology

JF - Frontiers in Microbiology

M1 - 811671

ER -

Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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