Virus–Host Interplay Between Poly (ADP-Ribose) Polymerase 1 and Oncogenic Gammaherpesviruses

Woo Chang Chung, Moon Jung Song

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


The gammaherpesviruses, include the Epstein–Barr virus, Kaposi’s sarcoma-associated herpesvirus, and murine gammaherpesvirus 68. They establish latent infection in the B lymphocytes and are associated with various lymphoproliferative diseases and tumors. The poly (ADP-ribose) polymerase-1 (PARP1), also called ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1) is a nuclear enzyme that catalyzes the transfer of the ADP-ribose moiety to its target proteins and participates in important cellular activities, such as the DNA-damage response, cell death, transcription, chromatin remodeling, and inflammation. In gammaherpesvirus infection, PARP1 acts as a key regulator of the virus life cycle: lytic replication and latency. These viruses also develop various strategies to regulate PARP1, facilitating their replication. This review summarizes the roles of PARP1 in the viral life cycle as well as the viral modulation of host PARP1 activity and discusses the implications. Understanding the interactions between the PARP1 and oncogenic gammaherpesviruses may lead to the identification of effective therapeutic targets for the associated diseases.

Original languageEnglish
Article number811671
JournalFrontiers in Microbiology
Publication statusPublished - 2022 Jan 14


  • ADP-ribosyltransferase diphtheria-toxin-like 1 (ARTD1)
  • Epstein-Barr virus (EBV)
  • Kaposi’s sarcoma-associated herpesvirus (KSHV)
  • gammaherpesvirus replication
  • murine gammaherpesvirus 68 (MHV-68)
  • poly (ADP-ribose) polymerase 1 (PARP1)
  • virus-host interaction

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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