Visceral adiposity and skeletal muscle mass are independently and synergistically associated with left ventricular structure and function: The Korean Genome and Epidemiology Study

Juri Park, Nan Hee Kim, Seong Hwan Kim, Jin Seok Kim, Yong Hyun Kim, Hong Euy Lim, Eung Ju Kim, Jin Oh Na, Goo Yeong Cho, Inkyung Baik, Doo Man Kim, Dong Seop Choi, Seung Ku Lee, Chol Shin

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Conclusions More visceral fat and less muscle mass are independently and synergistically associated with an increase in LV mass index and impairment of LV diastolic parameters. Further research is needed to explore the complex mechanisms underlying these associations.

Methods A total of 1941 participants without known cardiovascular disease were enrolled from the Korean Genome and Epidemiology Study. Visceral fat area (VFA) was assessed by computed tomography. Appendicular skeletal muscle mass (ASM) was estimated by dual-energy X-ray absorptiometry and was used as a percentage of body weight (ASM/Wt). LV structure and function were assessed by tissue Doppler imaging (TDI) echocardiography.

Results Across VFA tertiles, ASM increased, but ASM/Wt decreased (all P < 0.001). In multivariate models adjusted for conventional cardiovascular risk factors, LV mass index and LV diastolic parameters, such as left atrial dimension, TDI Ea velocity, and E/Ea ratio, were significantly impaired as VFA increased. On the other hand, an increase in ASM/Wt was associated with a decrease in LV mass index and improvement of LV diastolic parameters. With regard to LV mass index and TDI Ea velocity, VFA and ASM/Wt showed synergistic effects (all P interaction < 0.05). When both VFA and ASM/Wt were simultaneously included in the same model, both remained independent predictors of LV mass index and TDI Ea velocity.

Background Obesity and low muscle mass may coexist as age-related changes in body composition. We aimed to investigate the effect of visceral adiposity and skeletal muscle mass on left ventricular (LV) structure and function in the general population.

Original languageEnglish
Pages (from-to)951-955
Number of pages5
JournalInternational Journal of Cardiology
Volume176
Issue number3
DOIs
Publication statusPublished - 2014 Oct 20

Bibliographical note

Funding Information:
This study was supported by grants ( 2009-E00454-00 and 2010-E71001-00 ) from the Korean Centers for Disease Control and Prevention , and partially supported by a grant ( K0903121 and K1132641 ) from the Korea University Medical Institute .

Publisher Copyright:
© 2014 Elsevier Ireland Ltd. All rights reserved.

Keywords

  • Diastole
  • Echocardiography
  • Epidemiology
  • Left ventricular mass
  • Skeletal muscle mass
  • Visceral adiposity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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