Visible to mid IR: A library of multispectral diagnostic imaging

Miae Won, Mingle Li, Hyeong Seok Kim, Pai Liu, Seyoung Koo, Subin Son, Jae Hong Seo, Jong Seung Kim

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


Fluorescence imaging is an essential and interdisciplinary optical technique that uses light signals from molecules, cells, and living organisms to visualize dynamic biological processes. Moreover, with recent remarkable breakthroughs in the development of chemical mechanisms (e.g., aggregation-induced emission, donor-π-acceptor electron manipulation for near IR region II fluorescence emission, multi-photon absorption and molecular rotor), nanofabrication technologies, and newly discovered biomarkers, the opportunities to generate multifunctional bespoke probes for the rapid analysis and highly accurate diagnosis of early-stage cancers have increased. In this article, we mainly review the recent advances in some representative small molecule-based fluorescence probes and their nanocomposites with an emphasis on the design principles to enhance the recognition selectivity/sensitivity, improve the signal-to-background ratio, amplify the fluorescence emission brightness, and optimize the tissue penetration depth. Furthermore, we highlight the current challenges and further opportunities from the viewpoint of the practical applications of this emerging field.

Original languageEnglish
Article number213608
JournalCoordination Chemistry Reviews
Publication statusPublished - 2021 Jan 1

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI Project No. 2018R1A3B1052702 , and NRF-2019M3E5D1A01068998 , J.S.K.) and funded by the Ministry of Education (Basic Science Research Program 2020R1A6A3A01100551 , M.W.). This research also was supported by the Korea Research Fellowship Program funded by the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (KRF Grant No. 2020H1D3A1A02080172 , M.L.L.)

Publisher Copyright:
© 2020 Elsevier B.V.


  • Diagnostic bioimaging
  • Fluorescent probe
  • Mid-infrared
  • Near-infrared
  • Visible

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry


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