TY - JOUR
T1 - Visible to mid IR
T2 - A library of multispectral diagnostic imaging
AU - Won, Miae
AU - Li, Mingle
AU - Kim, Hyeong Seok
AU - Liu, Pai
AU - Koo, Seyoung
AU - Son, Subin
AU - Seo, Jae Hong
AU - Kim, Jong Seung
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (CRI Project No. 2018R1A3B1052702 , and NRF-2019M3E5D1A01068998 , J.S.K.) and funded by the Ministry of Education (Basic Science Research Program 2020R1A6A3A01100551 , M.W.). This research also was supported by the Korea Research Fellowship Program funded by the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (KRF Grant No. 2020H1D3A1A02080172 , M.L.L.)
Publisher Copyright:
© 2020 Elsevier B.V.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - Fluorescence imaging is an essential and interdisciplinary optical technique that uses light signals from molecules, cells, and living organisms to visualize dynamic biological processes. Moreover, with recent remarkable breakthroughs in the development of chemical mechanisms (e.g., aggregation-induced emission, donor-π-acceptor electron manipulation for near IR region II fluorescence emission, multi-photon absorption and molecular rotor), nanofabrication technologies, and newly discovered biomarkers, the opportunities to generate multifunctional bespoke probes for the rapid analysis and highly accurate diagnosis of early-stage cancers have increased. In this article, we mainly review the recent advances in some representative small molecule-based fluorescence probes and their nanocomposites with an emphasis on the design principles to enhance the recognition selectivity/sensitivity, improve the signal-to-background ratio, amplify the fluorescence emission brightness, and optimize the tissue penetration depth. Furthermore, we highlight the current challenges and further opportunities from the viewpoint of the practical applications of this emerging field.
AB - Fluorescence imaging is an essential and interdisciplinary optical technique that uses light signals from molecules, cells, and living organisms to visualize dynamic biological processes. Moreover, with recent remarkable breakthroughs in the development of chemical mechanisms (e.g., aggregation-induced emission, donor-π-acceptor electron manipulation for near IR region II fluorescence emission, multi-photon absorption and molecular rotor), nanofabrication technologies, and newly discovered biomarkers, the opportunities to generate multifunctional bespoke probes for the rapid analysis and highly accurate diagnosis of early-stage cancers have increased. In this article, we mainly review the recent advances in some representative small molecule-based fluorescence probes and their nanocomposites with an emphasis on the design principles to enhance the recognition selectivity/sensitivity, improve the signal-to-background ratio, amplify the fluorescence emission brightness, and optimize the tissue penetration depth. Furthermore, we highlight the current challenges and further opportunities from the viewpoint of the practical applications of this emerging field.
KW - Diagnostic bioimaging
KW - Fluorescent probe
KW - Mid-infrared
KW - Near-infrared
KW - Visible
UR - http://www.scopus.com/inward/record.url?scp=85092304047&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2020.213608
DO - 10.1016/j.ccr.2020.213608
M3 - Review article
AN - SCOPUS:85092304047
SN - 0010-8545
VL - 426
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 213608
ER -