Vitamin D receptor FokI, BsmI, ApaI, and TaqI polymorphisms and susceptibility to ovarian cancer: A meta-analysis

Objective: The goal of this study was to explore whether vitamin D receptor (VDR) polymorphisms are associated with susceptibility to ovarian cancer. Methods: Meta-analyses were conducted on the associations between the VDR FokI, BsmI, ApaI, and TaqI polymorphisms and ovarian cancer. Results: A total of 12 comparison studies were considered in the meta-analysis, which involved 3716 patients and 5059 controls. Meta-analysis of the VDR FokI polymorphism showed an association between ovarian cancer and the f allele in European populations (OR=1.094, 95% CI=1.028-1.163, p=0.004). Meta-analysis revealed an association between ovarian cancer and the ApaI A allele in all study subjects and Europeans as a sub-group (OR=1.235, 95% CI=1.019-1.497, p=0.032 and OR=1.287, 95% CI=1.029-1.609, p=0.027, respectively). No association was found between ovarian cancer and the BsmI and Taq polymorphisms (OR for B allele=1.084, 95% CI=0.936-1.255, p=0.280, OR for the T allele=OR=0.847, 95% CI=0.706-1.270, p=0.716). Conclusions: This meta-analysis suggests that the VDR FokI and ApaI polymorphisms are associated with susceptibility to ovarian cancer in European populations.