TY - JOUR
T1 - Volumetric and shape analysis of hippocampal subfields in unilateral mesial temporal lobe epilepsy with hippocampal atrophy
AU - Kim, Jung Bin
AU - Suh, Sang il
AU - Kim, Ji Hyun
N1 - Funding Information:
This work was supported in part by the National Research Foundation of Korea Grant funded by the Korean Government (Grant Nos. 20100004827 , 20110005418 ) and an unrestricted grant from Korea University (to J.H. Kim). The authors are very grateful to the participants for taking part in the present study.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2015/11
Y1 - 2015/11
N2 - Objective: The hippocampus consists of several functionally and histologically different subfields that are known to be differentially affected in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE). Using automated MRI analyses, we aimed to investigate atrophy patterns of hippocampal subfields and their relationships with clinical characteristics in a homogenous group of unilateral MTLE. Methods: Twenty-four left MTLE patients, 23 right MTLE patients, and 41 control subjects were scanned on a 3. T MR scanner. Automated volumetry and shape analysis were used to assess volume and shape changes of hippocampal subfields in MTLE patients relative to controls. Within-group correlations were performed between subfield volumes and clinical variables in patients. Results: Compared to controls, left and right MTLE patients exhibited significant volume reductions in ipsilateral whole hippocampus and subfields including CA1, CA2-3, CA4-DG, presubiculum, and subiculum (corrected p<. 0.05). Regional inward shape deformation mainly localized to ipsilateral CA1 and adjacent subiculum was found in left and right MTLE patients relative to controls (corrected p<. 0.05). Longer disease duration was related to smaller volumes of left CA1, presubiculum, and subiculum in left MTLE, and right CA1 in right MTLE. Conclusion: We found overall volume reductions in ipsilateral hippocampal subfields in patients with unilateral MTLE, in accordance with known pathologic findings. Our findings of regional atrophy in ipsilateral CA1 and subiculum on shape analysis and an inverse relationship between disease duration and ipsilateral CA1 volume implicate an important role of CA1 and subiculum in the pathogenesis underlying MTLE.
AB - Objective: The hippocampus consists of several functionally and histologically different subfields that are known to be differentially affected in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE). Using automated MRI analyses, we aimed to investigate atrophy patterns of hippocampal subfields and their relationships with clinical characteristics in a homogenous group of unilateral MTLE. Methods: Twenty-four left MTLE patients, 23 right MTLE patients, and 41 control subjects were scanned on a 3. T MR scanner. Automated volumetry and shape analysis were used to assess volume and shape changes of hippocampal subfields in MTLE patients relative to controls. Within-group correlations were performed between subfield volumes and clinical variables in patients. Results: Compared to controls, left and right MTLE patients exhibited significant volume reductions in ipsilateral whole hippocampus and subfields including CA1, CA2-3, CA4-DG, presubiculum, and subiculum (corrected p<. 0.05). Regional inward shape deformation mainly localized to ipsilateral CA1 and adjacent subiculum was found in left and right MTLE patients relative to controls (corrected p<. 0.05). Longer disease duration was related to smaller volumes of left CA1, presubiculum, and subiculum in left MTLE, and right CA1 in right MTLE. Conclusion: We found overall volume reductions in ipsilateral hippocampal subfields in patients with unilateral MTLE, in accordance with known pathologic findings. Our findings of regional atrophy in ipsilateral CA1 and subiculum on shape analysis and an inverse relationship between disease duration and ipsilateral CA1 volume implicate an important role of CA1 and subiculum in the pathogenesis underlying MTLE.
KW - Hippocampal sclerosis
KW - Hippocampal subfields
KW - Mesial temporal lobe epilepsy
KW - Shape analysis
KW - Volumetry
UR - http://www.scopus.com/inward/record.url?scp=84946202337&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2015.09.004
DO - 10.1016/j.eplepsyres.2015.09.004
M3 - Article
C2 - 26425829
AN - SCOPUS:84946202337
SN - 0920-1211
VL - 117
SP - 74
EP - 81
JO - Epilepsy Research
JF - Epilepsy Research
ER -