Water-soluble two-photon fluorophores based on paracyclophane

Han Young Woo, Guillermo C. Bazan

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


We report the synthesis, linear and nonlinear spectroscopy of the paracyclophane-based two-photon absorption (TPA) fluorophores. Two-photon induced fluorescence (TPIF) measurements in water show a substantial decrease in TPA cross section () and fluorescence quantum yield (), relative to toluene. We note that to obtain optimum two-photon action cross sections () in water, one needs to fine tune the intramolecular charge transfer (ICT). Microenvironment modulation using the micellar structure in water increases values similar to those obtained in toluene. The measured values in water are the highest among reported so far, suggesting important guidelines for designing of optimized TPIF molecular-labels.

Original languageEnglish
Pages (from-to)928-933
Number of pages6
JournalMolecular Crystals and Liquid Crystals
Publication statusPublished - 2008
Externally publishedYes


  • Bioimaging
  • Paracyclophane
  • TPA molecular label
  • Two-photon absorption

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics


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