Weight gain associated with the α2a-adrenergic receptor -1291 C/G polymorphism and olanzapine treatment

Young Min Park, Young Cho Chung, Seung Hwan Lee, Kang Joon Lee, Hyun Kim, Young Chan Byun, Se Won Lim, Jong Woo Paik, Heon Jeong Lee

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


Weight gain can be an adverse effect of antipsychotics and is an important factor for long-term health and treatment compliance. Many reports have shown that the α2-adrenergic receptor may be related to eating behaviors or lipolytic activities, both associated with body weight change. We hypothesized that there might be a relationship between the α 2a-adrenergic receptor -1291 C/G polymorphism and olanzapine-induced weight gain. A group of 62 Korean schizophrenic patients participated in a study; weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the -1291 C/G polymorphism was performed on all participants. Body weight changes from baseline to endpoint were significantly associated with genotypes (P = 0.028). The frequency of the G allele was significantly higher in subjects who had severe weight gain (defined as a more than 10% weight gain from baseline) compared to subjects who did not have extreme weight gain (less than 10% weight gain from baseline) (X2 = 6.120, P = 0.013; OR = 2.58, 95% CI = 1.21-5.51). Therefore, the findings from this study support a relationship between the -1291 C/G polymorphism of the α2a-adrenergic receptor and weight gain in Korean schizophrenic patients receiving olanzapine treatment.

Original languageEnglish
Pages (from-to)394-397
Number of pages4
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Issue number4
Publication statusPublished - 2006 Jun 5


  • Olanzapine
  • Polymorphisms
  • Schizophrenia
  • Weight gain
  • α-adrenergic receptor

ASJC Scopus subject areas

  • Genetics(clinical)
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience


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