@inproceedings{961e9dc4bc47416aae9cdb4c5533258d,
title = "Well-based microfluidic chip for monitoring non-contacting cell-to-cell interactions through microchannel",
abstract = "We present a new well-based microfluidic cell culture chip for monitoring non-contacting cell-to-cell interactions through micro-channels between chambers. The chip is fabricated with PDMS layers using SU-8 as molds. The fabricated chip was applied to monitor non-contacting cell-to-cell interaction between human glioblastoma cells and tau-engineered cells to study the association between malignant brain tumor and Alzheimer's disease (AD). Our results clearly demonstrated that the secreted components from glioblastoma cells enhanced tau aggregation. We have successfully demonstrated that the proposed well-based cell-to-cell interaction-monitoring chip can make two different cells interact through micro-channels without contacting each other using interactions between tau-BiFC cells and glioblastoma cells.",
keywords = "Cell to cell interaction, PDMS molding, SU-8 mold, glioblastoma cell, microfluidic chip, non-contacting, tau aggregation",
author = "Myounggun Jeon and Tak, {Hey Jin} and Kim, {Yun Kyung} and Yoon, {Eui Sung} and Sehyun Shin and Cho, {Il Joo}",
year = "2013",
doi = "10.1109/Transducers.2013.6626792",
language = "English",
isbn = "9781467359818",
series = "2013 Transducers and Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013",
pages = "418--421",
booktitle = "2013 Transducers and Eurosensors XXVII",
note = "2013 17th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS 2013 ; Conference date: 16-06-2013 Through 20-06-2013",
}
