Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS

Bangjian Dong, Lijun An, Xueyuan Yang, Xuke Zhang, Jie Zhang, Muhetaer Tuerhong, Da Qing Jin, Yasushi Ohizumi, Dongho Lee, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

A phytochemical study to obtain new nitric oxide (NO) inhibitors resulted in the isolation of five new withanolides from the whole plants of Physalis peruviana. The structures were determined on the basis of extensive NMR spectroscopic data analysis as well as the time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculations. The NO inhibitory effects were examined by inhibiting NO release in lipopolysaccharide-stimulated murine microglial BV-2 cells. Molecular docking studies showed the strong interactions of bioactive compounds with the inducible nitric oxide synthase (iNOS) protein, revealing the potential mechanism of NO inhibition of bioactive compounds.

Original languageEnglish
Pages (from-to)585-593
Number of pages9
JournalBioorganic Chemistry
Volume87
DOIs
Publication statusPublished - 2019 Jun

Bibliographical note

Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107 , 21642016 , and 21372125 ), the National Key Research and Development Program of China (No. 2018YFA0507204 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), the Hundred Young Academic Leaders Program of Nankai University , and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources ( Guangxi Normal University , No. CMEMR2018-B02 ).

Publisher Copyright:
© 2019 Elsevier Inc.

Keywords

  • Molecular docking
  • NO inhibitors
  • Physalis peruviana
  • Withanolides
  • iNOS

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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