We fabricated diclofenac-immobilized polycaprolactone (DFN/PCL) fibrous sheets to improve tendon healing of rabbits with collagenase-induced Achilles tendinitis. DFN/PCL have anti-inflammatory effects related to suppression of mRNA levels of pro-inflammatory factors including COX-2, IL-6, TNF-α and MMP-3 in inflamed tenocytes and tendon tissues of rabbits with Achilles tendinitis as well as those of anti-inflammatory cytokines including IL-4, IL-10, and IL-13. In vivo studies, wrapping of tendon tissues with DFN/PCL fibrous sheets may afford superior tendon healing, with decreased inflammatory cells, increased collagen content, restored collagen fiber organization, and improved mechanical strength. This approach will be a promising treatment from Achilles tendinitis.
Bibliographical noteFunding Information:
This study was supported by a grant from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea ( HI13C1501 ).
© 2019 The Korean Society of Industrial and Engineering Chemistry
- Achilles tendinitis
- Fibrous sheet
- Tendon healing
ASJC Scopus subject areas
- General Chemical Engineering