X-ray scattering effect on the heterogeneous dose distribution in a cell box

Myonggeun Yoon; Jungwook Shin; Jungwon Kwak; Dongho Shin; Sung Yong Park; Se Byeong Lee; Doo Hyun Lee; Kyung Hwan Shin; Hong Ryull Pyo; Joo Young Kim; Kwan Ho Cho

doi:10.1007/978-3-540-36841-0_515

X-ray scattering effect on the heterogeneous dose distribution in a cell box

Myonggeun Yoon, Jungwook Shin, Jungwon Kwak, Dongho Shin, Sung Yong Park, Se Byeong Lee, Doo Hyun Lee, Kyung Hwan Shin, Hong Ryull Pyo, Joo Young Kim, Kwan Ho Cho

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The dose distribution in a cell box is very important factor for the radiobiology experiment since it affects the cell survival probabilities. When the x-ray is irradiated to the closed (or sealed) cell box, which is frequently used for the experiment of oxygen enhancement ratio (OER) research, it is possible that x-ray scattering effect by cell boxes may cause the inhomogeneous dose distribution within a cell box. In this study, we have investigated the inhomogeneity of the dose distribution with three different sizes of cubical cell boxes, whose side lengths are 10, 15 and 20 cm. The difference of the doses at the center of 10 cm box and 20 cm box was measured to be less than 2 % for both 6 MV and 15 MV x-ray irradiation. That indicates the absolute dose at the center of cell box doesn’t much depend on the size of cell box. Unlike the absolute dose value at the center of box, the relative dose distribution in a cell box has the strong dependency upon the condition of the cell box. The results show that the percentage showing more than 10 % dose difference to the average dose value goes up to ~ 40 %. Our experimental evidence suggests that when the closed box is used for the radiobiological experiment, the dose inhomogeneity within the cell box is not negligible and the location of the cells within a box should be carefully designed.

Original language	English
Title of host publication	IFMBE Proceedings
Editors	Sun I. Kim, Tae Suk Suh
Publisher	Springer Verlag
Pages	2047-2050
Number of pages	4
Edition	1
ISBN (Print)	9783540368397
DOIs	https://doi.org/10.1007/978-3-540-36841-0_515
Publication status	Published - 2007
Externally published	Yes
Event	10th World Congress on Medical Physics and Biomedical Engineering, WC 2006 - Seoul, Korea, Republic of Duration: 2006 Aug 27 → 2006 Sept 1

Publication series

Name	IFMBE Proceedings
Number	1
Volume	14
ISSN (Print)	1680-0737
ISSN (Electronic)	1433-9277

Other

Other	10th World Congress on Medical Physics and Biomedical Engineering, WC 2006
Country/Territory	Korea, Republic of
City	Seoul
Period	06/8/27 → 06/9/1

Bibliographical note

Publisher Copyright:
© International Federation for Medical and Biological Engineering 2007.

Keywords

Cell box
Homogeneity
OER
Radiobiology
Scattering

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering

Access to Document

10.1007/978-3-540-36841-0_515

Cite this

Yoon, M., Shin, J., Kwak, J., Shin, D., Park, S. Y., Lee, S. B., Lee, D. H., Shin, K. H., Pyo, H. R., Kim, J. Y., & Cho, K. H. (2007). X-ray scattering effect on the heterogeneous dose distribution in a cell box. In S. I. Kim, & T. S. Suh (Eds.), IFMBE Proceedings (1 ed., pp. 2047-2050). (IFMBE Proceedings; Vol. 14, No. 1). Springer Verlag. https://doi.org/10.1007/978-3-540-36841-0_515

Yoon, M, Shin, J, Kwak, J, Shin, D, Park, SY, Lee, SB, Lee, DH, Shin, KH, Pyo, HR, Kim, JY & Cho, KH 2007, X-ray scattering effect on the heterogeneous dose distribution in a cell box. in SI Kim & TS Suh (eds), IFMBE Proceedings. 1 edn, IFMBE Proceedings, no. 1, vol. 14, Springer Verlag, pp. 2047-2050, 10th World Congress on Medical Physics and Biomedical Engineering, WC 2006, Seoul, Korea, Republic of, 06/8/27. https://doi.org/10.1007/978-3-540-36841-0_515

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abstract = "The dose distribution in a cell box is very important factor for the radiobiology experiment since it affects the cell survival probabilities. When the x-ray is irradiated to the closed (or sealed) cell box, which is frequently used for the experiment of oxygen enhancement ratio (OER) research, it is possible that x-ray scattering effect by cell boxes may cause the inhomogeneous dose distribution within a cell box. In this study, we have investigated the inhomogeneity of the dose distribution with three different sizes of cubical cell boxes, whose side lengths are 10, 15 and 20 cm. The difference of the doses at the center of 10 cm box and 20 cm box was measured to be less than 2 % for both 6 MV and 15 MV x-ray irradiation. That indicates the absolute dose at the center of cell box doesn{\textquoteright}t much depend on the size of cell box. Unlike the absolute dose value at the center of box, the relative dose distribution in a cell box has the strong dependency upon the condition of the cell box. The results show that the percentage showing more than 10 % dose difference to the average dose value goes up to ~ 40 %. Our experimental evidence suggests that when the closed box is used for the radiobiological experiment, the dose inhomogeneity within the cell box is not negligible and the location of the cells within a box should be carefully designed.",

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AU - Yoon, Myonggeun

AU - Shin, Jungwook

AU - Kwak, Jungwon

AU - Shin, Dongho

AU - Park, Sung Yong

AU - Lee, Se Byeong

AU - Lee, Doo Hyun

AU - Shin, Kyung Hwan

AU - Pyo, Hong Ryull

AU - Kim, Joo Young

AU - Cho, Kwan Ho

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AB - The dose distribution in a cell box is very important factor for the radiobiology experiment since it affects the cell survival probabilities. When the x-ray is irradiated to the closed (or sealed) cell box, which is frequently used for the experiment of oxygen enhancement ratio (OER) research, it is possible that x-ray scattering effect by cell boxes may cause the inhomogeneous dose distribution within a cell box. In this study, we have investigated the inhomogeneity of the dose distribution with three different sizes of cubical cell boxes, whose side lengths are 10, 15 and 20 cm. The difference of the doses at the center of 10 cm box and 20 cm box was measured to be less than 2 % for both 6 MV and 15 MV x-ray irradiation. That indicates the absolute dose at the center of cell box doesn’t much depend on the size of cell box. Unlike the absolute dose value at the center of box, the relative dose distribution in a cell box has the strong dependency upon the condition of the cell box. The results show that the percentage showing more than 10 % dose difference to the average dose value goes up to ~ 40 %. Our experimental evidence suggests that when the closed box is used for the radiobiological experiment, the dose inhomogeneity within the cell box is not negligible and the location of the cells within a box should be carefully designed.

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ER -

X-ray scattering effect on the heterogeneous dose distribution in a cell box

Abstract

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Bibliographical note

Keywords

ASJC Scopus subject areas

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