Yeast hydrolysate reduces body fat of dietary obese rats

K. M. Kim, U. J. Chang, D. H. Kang, J. M. Kim, Y. M. Choi, H. J. Suh

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The purpose of this study was to assess the antiobesity effect of the yeast hydrolysate (DNF) on the body weight, body fat and plasma lipids levels of high-fat fed rats. The weight gain of the HF (high fat diet) (162.58 ± 6.68 g) was significantly (p < 0.05) greater than that of DNF-1, DNF-2, (high fat diet with DNF of 0.5 and 1.0 g/kg body weight, respectively) and control groups (143.19 ± 7.33 g, 139.20 ± 8.36 g, 130.23 ± 8.02 g, respectively). The wet weight of the epididymal fat and the perirenal fat pads of the DNF-1, DNF-2 and control groups were reduced significantly (p < 0.05). A significant (p < 0.05) increase of HDL-cholesterol level of the DNF-2 and control groups was observed. However, there was no significant difference between DNF-1 and DNF-2. It was also found that the triacylglycerol (TG) levels decreased significantly (p < 0.05) in the DNF-2 group from that of the HF, but there was no significant (p < 0.05) difference between DNF-1 and DNF-2.

Original languageEnglish
Pages (from-to)950-953
Number of pages4
JournalPhytotherapy Research
Issue number11
Publication statusPublished - 2004 Nov


  • Hypolipidaemic effect
  • Triacyglycerol
  • Yeast hydrolysate

ASJC Scopus subject areas

  • Pharmacology


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