Zaprinast activates MAPKs, NFκB, and Akt and induces the expressions of inflammatory genes in microglia

Keyphrases

• AKT1 8%
• Carbon Tetrachloride 8%
• CD14 8%
• Chemokine (C-C motif) Ligand 2 (CCL2) 25%
• CXCL1 16%
• CXCL2 8%
• Cyclic GMP 8%
• Cyclooxygenase-2 8%
• ERK2 8%
• Gene Expression 8%
• Inducible Nitric Oxide Synthase 25%
• Inflammatory Genes 100%
• Interleukin-1β 33%
• Interleukin-6 16%
• Lipopolysaccharide 50%
• Lipopolysaccharide-induced 16%
• LY294002 8%
• Microglia 100%
• Microglial Activation 25%
• MRNA Expression 16%
• P38 MAPK Pathway 8%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 8%
• Pathway Expression 8%
• PD98059 8%
• Phosphodiesterase 8%
• Phosphorylation 16%
• Return to Normal 8%
• SB203580 8%
• Signaling Genes 8%
• Signaling Mechanism 8%
• Signaling Pathway 8%
• SP600125 8%
• Zaprinast 100%

Neuroscience

• CCL2 25%
• CD14 8%
• Cell Signaling 8%
• CXCL1 16%
• CXCL2 8%
• Gene Expression 8%
• Interleukin 6 16%
• Lipopolysaccharide 66%
• LY294002 8%
• MAPK Signaling 8%
• Messenger RNA 16%
• Microglia 100%
• Mitogen Activated Protein Kinase 3 8%
• Mitogen-Activated Protein Kinase 100%
• P38 Mitogen-Activated Protein Kinases 16%
• Phosphodiesterase 8%
• Signaling Mechanism 8%
• Zaprinast 100%

Pharmacology, Toxicology and Pharmaceutical Science

• 2 (2 Amino 3 Methoxyphenyl)chromone 8%
• 2 Morpholino 8 Phenylchromone 8%
• anthra[1,9 Cd]pyrazol 6(2h) One 8%
• Interleukin 6 16%
• Lipopolysaccharide 66%
• Messenger RNA 16%
• Mitogen Activated Protein Kinase 3 8%
• Phosphodiesterase 8%
• SB 203580 8%
• Tumor Necrosis Factor 25%
• Zaprinast 100%