Alginate zinc hydrogel loaded with zinc insulin hexamer was prepared and characterized for oral insulin administration. The hydrogel was fabricated by dripping zinc insulin hexamer into sodium alginate solution and followed by crosslinking by zinc chloride. SEM image reveals the zinc insulin hexamer was integrated into the matrix of hydrogel. Zinc insulin hexamer loaded hydrogel shows no obvious cytotoxicity to both HT29 and Caco-2 cells. The developed hydrogel retards the burst release of insulin in simulated gastric fluid but promotes the release when in simulated intestinal fluid. In the diabetic mice, zinc insulin hexamer loaded alginate hydrogel demonstrates significant and prolonged hypoglycemic effect.
|Number of pages||9|
|Journal||European Journal of Pharmaceutics and Biopharmaceutics|
|Publication status||Published - 2022 Oct|
Bibliographical noteFunding Information:
This work is supported by National Natural Science Foundation of China (31700015).
© 2022 Elsevier B.V.
- Control release
- Sodium alginate
ASJC Scopus subject areas
- Pharmaceutical Science