TY - JOUR
T1 - ΔNp63 protein expression in uterine cervical and endometrial cancers
AU - Lin, Zhenhua
AU - Liu, Mingzhu
AU - Li, Zhuhu
AU - Kim, Changheon
AU - Lee, Eungseok
AU - Kim, Insun
N1 - Funding Information:
Acknowledgment This study was supported by National Natural Science Foundation of China (no. 30560047), The Excellent Youth ScientiWc Study Fund of Jilin Province (no. 20050115) and Brain Korea 21 Project.
PY - 2006/12
Y1 - 2006/12
N2 - Purpose: To investigate the significance of p63 expression in uterine cervical and endometrial cancers. Materials and methods: ΔNp63 protein expression was studied in a variety of 127 cases of uterine cervical lesions (20 non-neoplastic cervices, 43 cervical intraepithelial neoplasia [CIN], 54 squamous cell carcinomas (SCCs), 40 adenocarcinomas, and 13 other histologic types) and 30 endometrioid type of endometrial adenocarcinomas by using immunohistochemistry. One SCC cell line (ME-180) and one adenocarcinoma cell line (HeLa) were also included. Results: In uterine cervix, the expression of ΔNp63 was increased with progression of CIN, and positive in all SCCs, transitional cell carcinomas, and adenoid basal carcinoma, but negative in all adenocarcinomas. Adenosquamous cell carcinoma and mixed neuroendocrine and squamous cell carcinoma were positive in squamous component, but not in adenocarcinoma and neuroendocrine carcinoma components. ME-180 cell line was positive, whereas HeLa cell line was negative. Endometrioid type of endometrial adenocarcinomas showed a positive staining in glandular (26.7%) and squamous component. Conclusions: Immunohistochemical staining for ΔNp63 is a powerful marker for squamous differentiation and useful in exclusion of glandular and neuroendocrine differentiation in uterine cervical cancers, but not always in endometrial cancers.
AB - Purpose: To investigate the significance of p63 expression in uterine cervical and endometrial cancers. Materials and methods: ΔNp63 protein expression was studied in a variety of 127 cases of uterine cervical lesions (20 non-neoplastic cervices, 43 cervical intraepithelial neoplasia [CIN], 54 squamous cell carcinomas (SCCs), 40 adenocarcinomas, and 13 other histologic types) and 30 endometrioid type of endometrial adenocarcinomas by using immunohistochemistry. One SCC cell line (ME-180) and one adenocarcinoma cell line (HeLa) were also included. Results: In uterine cervix, the expression of ΔNp63 was increased with progression of CIN, and positive in all SCCs, transitional cell carcinomas, and adenoid basal carcinoma, but negative in all adenocarcinomas. Adenosquamous cell carcinoma and mixed neuroendocrine and squamous cell carcinoma were positive in squamous component, but not in adenocarcinoma and neuroendocrine carcinoma components. ME-180 cell line was positive, whereas HeLa cell line was negative. Endometrioid type of endometrial adenocarcinomas showed a positive staining in glandular (26.7%) and squamous component. Conclusions: Immunohistochemical staining for ΔNp63 is a powerful marker for squamous differentiation and useful in exclusion of glandular and neuroendocrine differentiation in uterine cervical cancers, but not always in endometrial cancers.
KW - Endometrial cancer
KW - Uterine cervical cancer
KW - ΔNp63
UR - http://www.scopus.com/inward/record.url?scp=33749477086&partnerID=8YFLogxK
U2 - 10.1007/s00432-006-0130-8
DO - 10.1007/s00432-006-0130-8
M3 - Article
C2 - 16804722
AN - SCOPUS:33749477086
SN - 0171-5216
VL - 132
SP - 811
EP - 816
JO - Journal of Cancer Research and Clinical Oncology
JF - Journal of Cancer Research and Clinical Oncology
IS - 12
ER -
