ε-Amino acids based on bicyclic skeleton: bicyclo[3.3.0]octane-5-amino-1-carboxylic acids

Sung Jin Yeo, Kyung Seok Jeong, Hogyu Han, Jaheon Kim, Nakcheol Jeong

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Tsc-protected ε-amino acids, bicyclo[3.3.0]octane-5-amino-1-carboxylic acids (1), ready to use in the solid-phase synthesis, are prepared from 4,4-diethylcarboxylic bicyclo[3.3.0]oct-2-enone (3), which is available in bulk from 2 through the catalytic Pauson-Khand reaction.

Original languageEnglish
Pages (from-to)7389-7393
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number41
DOIs
Publication statusPublished - 2006 Oct 9

Bibliographical note

Funding Information:
This work was financially supported by the Basic Research Program (R02-2002-000-00128-0) and CMDS from KOSEF to N.J. and the Korea Research Foundation Grant (KRF-2003-015-C00377) CRM to H.H. S.J.Y. and K.S.J. are grateful to the BK21 program for the fellowship.

Keywords

  • Bicyclic amino acid
  • Pauson-Khand reaction
  • Solid phase synthesis
  • Tsc amine-protecting group
  • Unnatural amino acid
  • ε-Amino acid

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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